Urinary Adiponectin Excretion: A Novel Marker for ... - Diabetes

points are necessary to substantiate these
findings. As all patients of our study were
selected by a previous history of
microalbuminuria, future studies will have to
address, whether the proposed association
between urinary adiponectin and
atherosclerosis can be confirmed in patients at
advanced stages of diabetic nephropathy, as
well as in non-albuminuric diabetes patients.
So far, conclusions can only be drawn for the
high-risk group of type 2 diabetes patients in
this study. Moreover, since the number of
histological samples examined in this study is
low, additional studies are clearly needed to
further elucidate the distribution pattern of
glomerular adiponectin in different renal
pathologies in order to substantiate the
potential role of adiponectin for glomerular
homeostasis in humans.
In conclusion, measurement of urinary
adiponectin may emerge as a novel and easyto-obtain
method for the clinical assessment
of vascular stress and CVD risk in T2DM that
needs to be validated in larger prospective
studies and different samples including
diabetes patients without a history of
microalbuminuria.
ACKNOWLEDGMENTS
This study was supported by the Dr.
Werner Jackstädt-Stiftung (MvE), the
Manfred Lautenschläger Stiftung (PPN, AB,
PMH), and by IZKF Erlangen, project A11
(VC, KA).
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Urinary adiponectin in type 2 diabetes