Drug Discovery Part I: Screening for Compounds Jim Wells ...

More documents

Recommendations

Info

% inhibition Assay quality and Hit selection Next Steps? • Retest • Determine mechanism • Optimize! compound # A hit is just the �rst step to discovering a drug Demo • Chemist in a hood
Introduction to Drug Discovery Thanks to Kate Augustyn, Steven Chen, and Kenny Ang References High-throughput screening assays for the identi�cation of chemical probes. Inglese J, et al. Nat Chem Biol. 2007 Aug; 3(8):466-79 Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Arkin MR, Wells JA. Nat Rev Drug Discov. 2004 Apr;3(4):301-17. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Deininger M, Buchdunger E, Druker BJ. Blood. 2005 Apr 1;105(7):2640-53 Making better drugs: Decision gates in non-clinical drug development. Pritchard JF, Jurima-Romet M, Reimer ML, Mortimer E, Rolfe B, Cayen MN. Nat Rev Drug Discov. 2003 Jul;2(7):542-53 Drug Discovery Part I: Screening for Compounds Thanks to Kate Augustyn Steven Chen Kenny Ang
Page 1 and 2: Drug Discovery Part I: Screening fo
Page 3 and 4: Target ID: what’s causing disease
Page 5 and 6: Goals for oral drugs (chemical prop
Page 7 and 8: Start with libraries of drug-like m
Page 9: Demo • Biochemical assays - Light

Drug Discovery Part I: Screening for Compounds Jim Wells ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?