Drug Discovery Part I: Screening for Compounds Jim Wells ...
Drug Discovery Part I: Screening for Compounds Jim Wells ...
Drug Discovery Part I: Screening for Compounds Jim Wells ...
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Target ID: what’s causing disease<br />
Target validation:<br />
What’s causing the disease?<br />
Infectious agent or host imbalance?<br />
Molecular target leading to disease<br />
• Bacteria: �nd target not in humans<br />
• Host imbalance:<br />
Replace underactive protein (insulin)<br />
Inhibit overactive protein (kinase)<br />
The genome (genetic space) is huge<br />
and lots to search<br />
• ~20,000 human genes that<br />
code <strong>for</strong> proteins<br />
• Which one is causing the disease
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