Drug Discovery Part I: Screening for Compounds Jim Wells ...

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Start with libraries of drug-like molecules

Functional

groups

~ 500,000

compounds

How to handle that many compounds?

• Miniaturization (1 – 100 uL)

• Automation

• Parallel pipetting

• Robotics

• Plate readers

Demo here

• freezers

• Demo liquid handler

• Demo plates

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Hit Identi�cation: getting on the board Ways to identify a hit • Start with a natural substrate and make drug-like • Start with someone else’s hit (“patent bust”) • Design a denovo hit by Structurebased Design • Screening (HTS or Fragment methods) You have to test A LOT of compounds to �nd a drug

Start with libraries of drug-like molecules Functional groups ~ 500,000 compounds How to handle that many compounds? • Miniaturization (1 – 100 uL) • Automation • Parallel pipetting • Robotics • Plate readers Demo here • freezers • Demo liquid handler • Demo plates

Page 1 and 2: Drug Discovery Part I: Screening fo
Page 3 and 4: Target ID: what’s causing disease
Page 5: Goals for oral drugs (chemical prop
Page 9 and 10: Demo • Biochemical assays - Light
Page 11: Introduction to Drug Discovery Than

Drug Discovery Part I: Screening for Compounds Jim Wells ...

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