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Drug Discovery Part I: Screening for Compounds Jim Wells ...

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Introduction to <strong>Drug</strong> <strong>Discovery</strong><br />

Thanks to Kate Augustyn, Steven Chen, and<br />

Kenny Ang<br />

References<br />

High-throughput screening assays <strong>for</strong> the identi�cation of<br />

chemical probes. Inglese J, et al. Nat Chem Biol. 2007 Aug;<br />

3(8):466-79<br />

Small-molecule inhibitors of protein-protein interactions:<br />

progressing towards the dream. Arkin MR, <strong>Wells</strong> JA. Nat<br />

Rev <strong>Drug</strong> Discov. 2004 Apr;3(4):301-17.<br />

The development of imatinib as a therapeutic agent <strong>for</strong><br />

chronic myeloid leukemia. Deininger M, Buchdunger E,<br />

Druker BJ. Blood. 2005 Apr 1;105(7):2640-53<br />

Making better drugs: Decision gates in non-clinical drug<br />

development. Pritchard JF, Jurima-Romet M, Reimer ML,<br />

Mortimer E, Rolfe B, Cayen MN. Nat Rev <strong>Drug</strong> Discov. 2003<br />

Jul;2(7):542-53<br />

<strong>Drug</strong> <strong>Discovery</strong><br />

<strong>Part</strong> I: <strong>Screening</strong> <strong>for</strong> <strong>Compounds</strong><br />

Thanks to<br />

Kate Augustyn<br />

Steven Chen<br />

Kenny Ang

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