Drug Discovery Part I: Screening for Compounds Jim Wells ...
Drug Discovery Part I: Screening for Compounds Jim Wells ...
Drug Discovery Part I: Screening for Compounds Jim Wells ...
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Hit Identi�cation: getting on the board<br />
Ways to identify a hit<br />
• Start with a natural substrate and<br />
make drug-like<br />
• Start with someone else’s hit<br />
(“patent bust”)<br />
• Design a denovo hit by Structurebased<br />
Design<br />
• <strong>Screening</strong> (HTS or Fragment<br />
methods)<br />
You have to test A LOT of compounds<br />
to �nd a drug
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