Appendix - CNIC
Appendix - CNIC
Appendix - CNIC
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SCIENTIFIC REPORT ´09<br />
Computer reconstruction (Amira 3D) of the spatial<br />
distribution of the activated Notch1 receptor (N1ICD) in a<br />
WT E9.5 mouse heart. N1ICD is labeled red and cell nuclei<br />
are blue. Note the predominant N1ICD expression in the<br />
ventricles (lv, rv) and atria (at).<br />
> MAJOR GRANTS<br />
- European Commission FP6 (LSHM-CT-2005-018630)<br />
- European Commission FP7, Initial Training Network (215761)<br />
- Ministerio de Ciencia e Innovación (SAF 2007-62445)<br />
- Ministerio de Ciencia e Innovación. FIS RETICS (TERCEL; RD06/0010/1013)<br />
- Ministerio de Ciencia e Innovación. FIS RETICS (RECAVA II; RD06/0014/0038)<br />
- Comunidad de Madrid (P-2006/ BIO-194). Coordinator and PI, JL de la Pompa<br />
- Centro Nacional de Investigaciones Cardiovasculares (FPIT <strong>CNIC</strong>-09)<br />
- Fundació La Marató TV3 (081731)<br />
SELECTED PUBLICATIONS<br />
1 Cardiovascular Developmental Biology<br />
Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M. Notch is a critical<br />
component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet (2009) 5: e1000662<br />
Gonzalez-Garcia S, Garcia-Peydro M, Martin-Gayo E, Ballestar E, Esteller M, Bornstein R, de la Pompa JL, Ferrando AA, Toribio ML.<br />
CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{α} gene expression in early human thymopoiesis and<br />
leukemia. J Exp Med (2009) 206: 779-91<br />
Perez-Pomares JM, de la Pompa JL. Tissue-patterned embryonic interactions in heart development: cell versus non-cell-autonomous<br />
molecular signalling and the origin of CHD. Nat Rev Cardiol (<strong>CNIC</strong> Edition) (2009) 6: 73-8<br />
de la Pompa JL. Notch signaling in cardiac development and disease. Pediatr Cardiol. (2009) 30: 643-50<br />
12<br />
Mice deficient for the Notch effector RBPJK develop aortic valve<br />
stenosis. (A, B) WT and RBPJK heterozygous (RBP KO/+) mice<br />
fed a normal diet (CC) have normal aortic valves. (C, D) RBP<br />
KO/+ mice fed a hypercholesterolemic diet (HC) show signs of<br />
valve calcifiaction (arrows). (E, F) RBP KO/+ mice fed a<br />
hypercholesterolemic diet plus vitamin D show signs of severe<br />
calcification (arrows in F).
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