Appendix - CNIC
Appendix - CNIC
Appendix - CNIC
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SCIENTIFIC REPORT ´09 3 Vascular Biology and Inflammation<br />
Analysis of angiogenesis and vascular integrity. Top: Human<br />
endothelial cells grown in vitro in 3D collagen I gels form capillarylike<br />
tubes. Bottom: PECAM-1 staining of endothelial junctions<br />
reveals the integrity of the blood vessels in the mouse diaphragm<br />
vasculature.<br />
> MAJOR GRANTS<br />
- Ministerio de Ciencia e Innovación (SAF2008-0214)<br />
- Ministerio de Ciencia e Innovación. FIS RETICS (RECAVA; RD/06/0014/1016)<br />
- Fundación Genoma España. MEICA Project<br />
SELECTED PUBLICATIONS<br />
44<br />
Macrophages and inflammation. Top: Mouse peritoneal macrophages<br />
display a polarized morphology in culture. Bottom: Mac-3 staining<br />
reveals the presence of macrophages in atherosclerotic plaques of<br />
LDLR -/- mice fed a high fat diet.<br />
Gonzalo P, Guadamillas MC, Hernandez-Riquer MV, Pollan A, Grande-Garcia A, Bartolome RA, Vasanji A, Ambrogio C, Chiarle R,<br />
Teixido J, Risteli J, Apte SS, del Pozo MA, Arroyo AG. MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling.<br />
Dev Cell (accepted)<br />
Yanez-Mo M, Barreiro O, Gonzalo P, Batista A, Megias D, Genis L, Sachs N, Sala-Valdes M, Alonso MA, Montoya MC, Sonnenberg A,<br />
Arroyo AG, Sanchez-Madrid F. MT1-MMP proteolytic activity is regulated through association with tetraspanin CD151 in primary<br />
endothelial cells. Blood (2008) 112: 3217-26<br />
Alfranca A, Lopez JM, Genis L, Lopez-Maderuelo D, Salvado D, Quesada AJ, Arroyo AG, Redondo JM. PGE2 induces angiogenesis via<br />
the MT1-MMP-mediated activation of the TGFβ/ALK5 signaling pathway. Blood (2008) 112: 1120-8
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