Appendix - CNIC

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SCIENTIFIC REPORT ´09 Evaluation of the differentiation potential of GFP-tagged mCPC. mCPC cultures stably transfected with an EGFP expression plasmid were treated with several differentiation stimuli. Markers of preferential lineage differentiation were analyzed by immunofluorescence and qPCR. > MAJOR GRANTS - Ministerio de Ciencia e Innovación. Programa Nacional de Internacionalización de la I+D (PLE 2009/0147). Sub-project coordinator, A. Bernad - Ministerio de Ciencia e Innovación. Programa Nacional de Internacionalización de la I+D (PLE2009 2009/0112). PI, M. A. González de la Peña - Ministerio de Ciencia e Innovación. Proyecto Singular Estratégico (PSE-01000-2009-3). Sub-project coordinator, A. Bernad - Ministerio de Ciencia e Innovación (SAF2008-02099). PI, A. Bernad - Ministerio de Ciencia e Innovación. Programa Nacional de Internacionalización de la I+D (PLE 2009/0100). Sub-project coordinator, A. Bernad - Ministerio de Ciencia e Innovación. FIS (PI071073). PI, E. Samper - Ministerio de Ciencia e Innovación (SAF 200802099). PI, A. Díez-Juan SELECTED PUBLICATIONS Bailey B, Izarra A, Alvarez R, Fischer KM, Cottage CT, Quijada P, Diez-Juan A, Sussman MA. Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med (2009) 4: 823-33 Gozalbo-Lopez B, Andrade P, Terrados G, de Andres B, Serrano N, Cortegano I, Palacios B, Bernad A, Blanco L, Marcos MA, Gaspar ML. A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol Cell Biol (2009) 29: 1266-75 Gonzalez MA, Gonzalez-Rey E, Rico L, Büscher D & Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology (2009) 136: 978-89 Lucas D, Escudero B, Ligos JM, Segovia JC, Estrada JC, Terrados G, Blanco L, Samper E, Bernad A. Altered hematopoiesis in mice lacking DNA polymerase micro is due to inefficient double-strand break repair. PLoS Genet (2009) 5: e1000389 Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med (2009) 46: 387-96 24 2 Regenerative Cardiology Evaluation of the genomic instability associated with extended in vitro culture of aSC. Interphase in situ fluorescence hybridization with centromere probes for human chromosomes 8 (red), 11 (green) and 17 (blue). Nuclei are counterstained with DAPI (gray). This image shows primary mesenchymal stem cells that are triploid for chromosome 8.
SCIENTIFIC REPORT ´09 > RESEARCH INTEREST Our laboratory researches the mammalian mitochondrial electron transport chain (MtETC) and H+-ATP synthase, which together constitute the oxidative phosphorylation (OXPHOS) system. We view this system as a functional entity, and use a range of approaches aimed at determining its role in health and disease. We are particularly interested in the role of the OXPHOS system in the development of the cardiovascular system, its relevance to ischemia-reperfusion, and its influence on microvascular blood flow. Currently very little is known about why, where and how impaired function of the OXPHOS system manifests in disease. One reason for this is that there are major deficiencies in the established models of the organization of the electron transport chain. Thus the main lesson from 25 2 Regenerative Cardiology Functional genetics of the oxidative phosphorylation system Head of Laboratory: José Antonio Enríquez Research Scientists: Acisclo Pérez Martos Patricio Fernández Silva Postdoctoral Researchers: Pilar Bayona Bafaluy Erika Fernández -Vizarra Nuria Garrido Pérez Patricia Meade Huerta Raquel Moreno Loshuertos Carmen Colás Ester Perales Clemente Predoctoral Researchers: Ricardo Marco Lázaro Ana Latorre Pellicer Esther Lapuente Brun Elena de Tomás Mateo Support Scientists: Nieves Movilla Meno Mª Concepción Jiménez research to date into human OXPHOS diseases is that our basic understanding is far from complete. In order to fill this gap, we are implementing high-throughput strategies to catalogue the set of the genes whose products participate in the biogenesis and regulation of the OXPHOS system (which we call the OXPHOME). We are also determining the factors that regulate the structural organization of the electron transport chain and the role that this superstructural organization plays in the production of reactive oxygen species (ROS). This area is linked to our interest in the role of ROS as mitochondrial second messengers and to our aim to deconstruct, in cellular models, the mammalian OXPHOS system into its functional components (electron transport, proton pumping and ATP synthesis). Fluid, solid and plasticity models of the mitochondrial OXPHOS system organization.
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