Master of Pharmacy - Nagpur University
Master of Pharmacy - Nagpur University
Master of Pharmacy - Nagpur University
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Semester-III<br />
Subject code: MPL-S13<br />
Subject: MOLECULAR PHARMACOLOGY AND TOXICOLOGY<br />
THEORY: 60 Hours (4 hrs. /week)<br />
1. Molecular mechanism <strong>of</strong> drug action: Receptor occupancy and cellular signaling<br />
systems such as G-proteins, cyclic nucleotides, calcium and phosphatidyl inositol. Ionic<br />
channels and their modulators.<br />
2. Endogenous bioactive molecules such as cytokines, neuropeptides and their<br />
modulators, neurosteroids, nitric oxide, phosphodiestrase enzyme and protein kinase C,<br />
arachidonic acid metabolites.<br />
3. Recent trends on different classes <strong>of</strong> receptors and drugs acting on them<br />
Angiotensin receptors, Excitatory amino acid receptors, Kinin receptors, Adrenoceptors,<br />
Low molecular weight heparins, Imidazole receptors, Cholinergic receptors, Dopamine<br />
receptors, Serotonin receptors, Hormone receptors, GABA receptors, Purinergic receptors,<br />
Glutamate receptors.<br />
4. Ion channel and their modulators: calcium, potassium, sodium and chloride channels<br />
5. Basic Concepts <strong>of</strong> Chronopharmacology and their implications to Drug Therapy. .<br />
6. Concept <strong>of</strong> gene therapy and recent development in the treatment <strong>of</strong> various hereditary<br />
diseases. Transgenic mouse and its applications. Human genome mapping and its potential<br />
in drug research.<br />
7. Toxicology: Principles <strong>of</strong> toxicology, elementary knowledged <strong>of</strong> systemic toxicology,<br />
manifestation <strong>of</strong> toxicology, Management and treatment <strong>of</strong> poisoning, immunotoxicity,<br />
toxic effect on genetic material and cell proliferation, non therapeutic toxicants, air<br />
pollutants, solvents, vapour and pesticides toxicity, food additives and contaminant toxicity,<br />
heavy metal toxicity, toxins <strong>of</strong> animal origin, radiations and radioactive material toxicity,<br />
adverse drug reactions, toxicity <strong>of</strong> drug overdosing and its management.<br />
RECOMMENDED BOOKS:<br />
1. Katzung, B.G; Basic and Clinical Pharmacology, Lange Medical Publisher, USA<br />
(2009) 11 th edition.<br />
2. Paul W. E. ed. Fundamental immunology, Lippincott-raven, Philadelpia 1999, 4 th<br />
edition.<br />
3. Bowman, W.C. and Rand, M.J.; Textbook <strong>of</strong> Pharmacology, Blackwell, Oxford 2 nd<br />
edition.<br />
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