The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
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10<br />
Franco, JG Jr et al, Reproductive Biomedicine Online, 2006<br />
�� Meta-analysis Meta analysis of 6 trials,<br />
comparing GnRH agonist and<br />
antagonist treatment for poor<br />
responders<br />
�� Antagonist <strong>–</strong> Multiple low dose<br />
antagonist (0.25 mg)<br />
�� Agonist <strong>–</strong> long protocol <strong>–</strong> 2<br />
- microdose flare <strong>–</strong> 4<br />
microdose<br />
�� No difference between GnRH agonist or<br />
antagonist in terms of cycle cancellation rate,<br />
number of mature oocytes, or pregnancy rate<br />
�� In analysis of GnRH agonist microdose flare vs<br />
antagonist (4 trials) - significantly higher rate of<br />
oocytes retreived in GnRH-a GnRH a flare cycles<br />
�� no difference in pregnancy outcomes<br />
�� More trials needed
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