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The Poor Responder – New Medical Treatment Poor Responders ...

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24<br />

Frattarelli, J et al, Fertility sterility 2007<br />

�� Retrospective cohort study of 1250 poor-<br />

responder women undergoing IVF<br />

�� Aspirin<br />

→ decreased platelet production of PGG<br />

→ lower level of Thromboxane<br />

→ vasodilation, increased blood flow in ovarian<br />

arteries<br />

→ improved quality of oocytes, higher<br />

implantation, pregnancy and live-birth live birth rates<br />

�� Step down protocol<br />

�� 417 women were treated with 81mg<br />

aspirin beginning during month prior to IVF<br />

cycle<br />

833 underwent standard protocol only

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