The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
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26<br />
Adjuvant L-arginine L arginine treatment for<br />
IVF in poor responders<br />
Battaglia, C et al, Human Reproduction, 1999<br />
�� Pre-cursor Pre cursor of nitric oxide<br />
�� Vasodilation → increased blood flow in ovarian arteries<br />
�� 34 poor responders, divided into :<br />
I - GnRH-a GnRH a + FSH<br />
II - GnRH-a GnRH a + FSH + L-arginine L arginine (daily supplementation<br />
until hCG)<br />
�� Hormone, US + Doppler<br />
�� arginine, citrulline, nitrite, nitrate and IGF-1 IGF<br />
�� 3 pregnancies in L-arginine L arginine group, all early pregnancy<br />
loss, none in control group<br />
�� Increased no oocytes<br />
�� Increased no ET<br />
�� Lower cancellation rates<br />
�� Significant Doppler flow improvement in uterine and<br />
perifollicular arteries <strong>–</strong> decreased blood flow resistance<br />
�� Inverse corretlation btwn doppler doppler PI and and estradiol estradiol<br />
concentration<br />
�� Significantly higher concentrations of <strong>–</strong> L-arginine, arginine, L-<br />
citrulline, nitrite, nitrate and IGF-1<br />
IGF
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