The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
The Poor Responder – New Medical Treatment Poor Responders ...
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14<br />
Testosterone cycle<br />
�� Less GT stimulation required<br />
�� Increased antral follicle count<br />
�� Increased serum androstenedione and<br />
IGF-1 IGF 1 in non-cancelled non cancelled vs cancelled<br />
(refelcting ovarian responsiveness to GT<br />
stimulation)<br />
Massin, N et al, Human Reproduction 2006<br />
�� Supplementation at time of recruitment might increase small antral antral<br />
follicle count and<br />
improve follicular sensitivity to FSH<br />
�� 53 women <strong>–</strong> 2 IVF cycles - before and after transdermal testosterone/placebo<br />
(randomized)<br />
�� <strong>Treatment</strong> of 1g/day for 15-20 15 20 days before the second stimulation, stimulation,<br />
during GnRH<br />
downregulation<br />
�� Significant increase in plasma testosterone for women treated with with<br />
testosterone<br />
compared with placebo<br />
�� No significant difference in plasma FSH, LH, AMH, inhibin B, estradiol, estradiol,<br />
Δ4-androstenedione androstenedione or antral follicle count<br />
� No significant difference in number of follicles, oocytes or embryos, but trend towards<br />
better outcome
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