“Crowd Control” Turning Cells into Organs via Collective Migration
“Crowd Control” Turning Cells into Organs via Collective Migration
“Crowd Control” Turning Cells into Organs via Collective Migration
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Wild Wild Type Type<br />
(WT) (WT)<br />
How do signals control tissue migration?<br />
CXCR4/SDF1 signaling guides tissue migration<br />
Cxcr4/SDF1-deficient<br />
Cxcr4 Cxcr4<br />
mutant mutant<br />
Key Unkowns That Can Be Addressed<br />
How do guidance signals guide tissues?<br />
How is the response to cues regulated collectively?<br />
Do cells within groups guide each other? If so, how?<br />
Tissue guidance can be mediated non-autonomously by a few leader cells.<br />
wt cxcr4 mutant
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