“Crowd Control” Turning Cells into Organs via Collective Migration

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Testing role of tissue-scale polarity by targeted laser dissection epithelial Tissue is polarised in terms of migratory potential. mesechyme-like ‘leaders’ 70 70 uM uM Rosettes ‘melt’ after leader ablation. “leading edge+rosettes’ configuration is highly robust. Enconsin-GFP
Mesenchymal Leaders + Epithelial Rosette = Directional Persistence Distance in microns 100 90 80 70 60 50 40 30 20 10 0 Mean displacement of cells in fragment including rosette Std Mean Displacement 20 40 60 80 100 120 140 160 Time in minutes MSD in microns 2 /minutes 35 30 25 20 15 10 5 0 Mean square displacement of cells in fragment Std Mean square Displacement 20 40 60 80 100 120 140 160 Time in minutes SDF1
Page 1 and 2: “Crowd Control” Turning Cells i
Page 3 and 4: Morphogenesis: “the origin of sha
Page 5 and 6: http://multimedia.mcb.harvard.edu/
Page 7 and 8: Dicty movie from Firtel lab (UCSD)
Page 9 and 10: Zebrafish allow the study of dynami
Page 11 and 12: What is it? The zebrafish lateral l
Page 13 and 14: Collective migration : a(nother) li
Page 15 and 16: Tissue Polarity/Directionality Requ
Page 17 and 18: The primordium treats the stripe of
Page 19 and 20: FGF ‘foci’ nucleate epithelial
Page 21: Testing role of tissue-scale polari

“Crowd Control” Turning Cells into Organs via Collective Migration

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