Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
f,_<br />
TOVABBKEPZES<br />
Fontos-e a thromhocyta aggregatio<br />
gätlilsa rn6r az 6rm(it6t el6tt is?<br />
DR. ot,vnszro sÄnnoR, DR. JENEs BnzsneET, DR. MISZ uÄnIa<br />
össznnocrllÄs<br />
Ma mär ismert a thrornlror:ytäk pathofizioldgiai szere-<br />
pe az arterioscleroticus 6rbetegsdg kialakuläsäban 6s<br />
ptogtesszi6jäban. Az is elfrrgadott, hogy a thrombor:y-<br />
ta aggregatio gätläsa k6slelteti a thronrlxrticus sziivr -<br />
mdnyek fell6p6s6t. Vizsga'rlatafurk sot'1ur 60 6tbereget<br />
monitolozturrL h6naporr keresztüI. A betegeinhet<br />
"gy<br />
k6t csrrportba osztottuk aszerint, hogy voh-e megelfiz(i<br />
6rnrtit6t., väsy neln? illetve ezen beläl több hclyelr is<br />
el6tirrdult-e az 6r'szrikület.<br />
A vizsgälatba azon 6r'beregek kerültek be, akilur6l<br />
az els(j m6r6ssel (MAI>2), hypernggregzrbilitzrst taläl-<br />
trurh. Ezt kiivet(ien IOO rug acetilszalicilsavat szedtek<br />
a betegek, 6s vizsghltuk a thnrnrbor:ytt aggregartios<br />
rendszer 6s coagulatios rendszer tübb param,6ter'6t.<br />
Eredm6nyeinkct 6rt6kelve megällarpftottuh, hogy az<br />
6r'betegek többs6gc a megel6z6 nätätt(fl tiiggetlenül is<br />
firkozott thrombocyta acgregatirival 61. Mind a müt6t<br />
el6tt. ä116, rnirrd az operält bctegek gÄtl6kezel6,sl'e szo-<br />
rulnnk, 6s 100 urg ar:etilszalir:ilsav nrhr nz els6 h6t na-<br />
pon belül eredrndnyesen csiikkenti a thrrrmbocyläk<br />
aktivälridhsät, 6s ezzel a thrornbotir:us rizikrit.<br />
KULCSSZAVAK<br />
th.r o r nb o cy t a funk t i 6, hy p e r ug gre grtb iI i t u.s, uc et ilsz u.li -<br />
ciJsnu, uggregoti tt g(ttläs<br />
Is inhibition of lhe platelet aggregation necessary<br />
beftl'e vascular surgery?<br />
SÄNDOR OLVASZTd M. D.,<br />
ERZSfBET JENES M. D.O NNÄH,q' MISZ M' D'<br />
The fhct that plarelets play an importamt role in the<br />
onset amd prrrgression of athenrsr:lerotit: vascular dise-<br />
asc has already been proved, It is also well lorown that<br />
by inhibiting the plntelet aggregation the appearance<br />
of the |hlombotir: complit:aliolts call be postponed.<br />
Duling our study we ulrttiJored 6O patients t'ith<br />
vasr:ulal diseascs for the petiod of one ntonth. The pa-<br />
tients havr: bcen dividetl inlo two groups upon Lhe ple-<br />
senr:e of a previous vasr:ular sutgery and those who<br />
hnd bave becn futtlrel subdivided on the basis of the<br />
nunrber of obstmr:tiols.<br />
Those prticnts have been involved in the study in<br />
whonr hypelaggrr:gability could be fbund fur the first<br />
examination (MAb2). Atierwards, lOO mg acetylsa-<br />
lir:ylir: ar:id has been admirristreted and the major pa-<br />
l':ulleJers of thc platelet 4ggregation and r:oagulation<br />
have been morritoled.<br />
flased r)n ()ul' r'r:suhs, we oanl say that fur the majo-<br />
rity of the patir:nls increased platelet aggregatiou cau<br />
be ftlurd regardless of :r previous vasculal inl.erventi-<br />
orr. All the patients, both befirre amd after surgery ne-<br />
ed prevention and 100 mg ar:etylsalir:ylir: acid seenls<br />
to be able to redur:e the platelet ar:tivity and thus the<br />
lisk of thlourbosis even duling the filst week.<br />
KEYWORDS<br />
plu.telet fiur.ctiort, hyperaggregubility, acetylsali.cyli.c<br />
tt c i.d, u, ggr e gati on. i nl t,ib iti ttrt.<br />
Erlretegs6gek, V. 6vfoly:rm 4.. sziun, l99Al4. r+5
Change language