Lezione Miastenia Guillain-Barrè - Facoltà di Medicina e Chirurgia ...

Hypothetical sequence
of events during
the induction and
effector phases of the
immune
response in the
peripheral nervous
system.
1. Circulating T cells are activated by unknown antigen, eg, P0 or P2. T
cells then adhere to the endothelial layer and migrate intraneurally.
2. T cells are activated by their specific antigen presented by professional
antigen presenting cells or by non-professional APC
3. T-cell activation leads to cytokine secretion that activates
macrophages, which release proinflammatory cytokines such as TNF,
OH -, complement factors, and PGE,
4. T cells activate B cells, which produce myelin-specific antibodies that
attach to the myelin sheath