Terapia innovativa: oltre il PEB? Relatore: Dr ... - Oncologia Rimini
Terapia innovativa: oltre il PEB? Relatore: Dr ... - Oncologia Rimini
Terapia innovativa: oltre il PEB? Relatore: Dr ... - Oncologia Rimini
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Prognostic factors in relapsed or refractory germ-cell tumors<br />
ASCO 2009 - Abstr # 5030<br />
A. Lorch, J. Beyer , C. Mollevi, M. Guerra, A. Kramar for the International Group on<br />
Prognostic Factors in Relapsed or Refractory Germ-Cell Tumors<br />
Multivariate analysis<br />
Hazard Ratio<br />
95% CI<br />
p<br />
Primary site<br />
Gonadal<br />
Retroperitoneal<br />
Mediastinal<br />
1<br />
1.35<br />
2.99<br />
[0.95; 1.93]<br />
[2.05; 4.36]<br />
< 0.0001<br />
Response first-line<br />
CR / PRm-<br />
PRm+ / SD<br />
PD<br />
1<br />
1.22<br />
1.60<br />
[0.96; 1.55]<br />
[1.10; 2.31]<br />
0.0346<br />
Prog.-free interval (PFI)<br />
>3 months<br />
≤ 3 months<br />
1<br />
1.24<br />
[1.01; 1.52]<br />
0.0391<br />
AFP at salvage<br />
Normal<br />
≤ 1000<br />
> 1000<br />
1<br />
1.26<br />
2.04<br />
[1.03; 1.53]<br />
[1.52; 2.73]<br />
< 0.0001<br />
HCG at salvage<br />
≤ 1000 or normal<br />
> 1000<br />
1<br />
1.55<br />
[1.23; 1.95]<br />
< 0.0001<br />
Liver, bone, brain salvage (LBB)<br />
No<br />
Yes<br />
1<br />
1.21<br />
[1.00; 1.46]<br />
0.0474
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