TRASCRIZIONE E MATURAZIONE DELL'RNA - Bgbunict.it

HETEROTRIMER
(A, B, C SUBUNITS)
BINDS PROMOTER
REGION WITH TFIID
TFIIA
DAB
TFIID
TFIIB
TWO DOMAIN:
N-TERMINAL
Zn-RIBBON
AND
TFIIF
CORE DOMAIN
HETEROTETRAMER
(RAP30) 2 (RAP74) 2
(RAP30) 2 BINDS RNA POL II
AND TFIIB. RAP74 INTERACTS
WITH DNA. TFIIF
STABILIZES THE
INTERACTION OF
RNA POLII WITH
PROMOTER AND STIMULATES
ELONGATION RATE
TFIIE
TFIIH
TFIIB INTERACTS WITH
SADDLE-LIKE LIKE DOMAIN OF
TBP AND WITH BENDED DNA
ON SIDES OF TATA BOX.
TBP/TFIIB COMPLEX
RECRUITS RNA POLII AND
OTHER GTF
P
TFIIE MODULATES
THE HELICASE AND
KINASE
ACTIVITIESOF TFIIH
BY STIMULATING CTD
DOMAIN RNA POLII
PHOSPHORYLATION
TFIIH
STIMULATES
PROMOTER
PHOSPHORYLATION OF
MELTING AND IT
RNA POLII CTD
HAS KINASE
STIMULATES PROMOTER
ACTIVITY
AGAINST RNA
MELTING AND
POL II
TRANSCRIPTION START