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Lægemidler med virkning på respirationsvejene Astma

Lægemidler med virkning på respirationsvejene Astma

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Corticosteroider - <strong>virkning</strong>smekanisme<br />

Hsp90<br />

GCS<br />

GCS receptor<br />

guarded by Hsp90<br />

DNA<br />

GCS receptor<br />

GCS receptorcomplex<br />

Transcription factor<br />

(eg. AP-1, NF-kB)<br />

Decoiling<br />

Transactivation<br />

Increase antiinflammatory proteins<br />

Side-effects (eg. metabolic)<br />

Transrepression<br />

Decrease inflammatory proteins<br />

Inhalationssteroider- bi<strong>virkning</strong>er<br />

Systemiske<br />

- suppression af HPA-aksen<br />

- væksthæmning<br />

- hudforandringer<br />

- (osteoporose, glaukom, katarakt)

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