esistant Staphylococcus aureus (1996-2004): report to the Joint MRSAWorking Party (Subgroup A). J Hosp Infect 63 Suppl 1:S45-70.9. Donnelly RF, McCarron PA, Tunney MM (2008) Antifungal photodynamictherapy. Microbiol Res 163:1-12.10. Engelhardt V, Krammer B, Plaetzer K (2010) Antibacterial photodynamictherapy using water-soluble formulations of hypericin or mTHPC is effectivein inactivation of Staphylococcus aureus. Photochem Photobiol Sci 9:365-369.11. Konopka K, Goslinski T (2007) Photodynamic therapy in <strong>de</strong>ntistry. J DentRes 86:694-707.12. Dovigo LN, Pavarina AC, Mima EG, Giampaolo ET, Vergani CE, BagnatoVS (2011) Fungicidal effect of photodynamic therapy against fluconazoleresistantCandida albicans and Candida glabrata. Mycoses 54:123-130.13. <strong>Ribeiro</strong> AP, Pavarina AC, Trinda<strong>de</strong> FZ, Inada NM, Bagnato VS, <strong>de</strong> SouzaCosta CA (2010) Photodynamic therapy associating Photogem and blue LEDon L929 and MDPC-23 cell culture. Cell Biol Int 34:343-351.14. Grinholc M, Szramka B, Kurlenda J, Graczyk A, Bielawski KP (2008)Bactericidal effect of photodynamic inactivation against methicillin-resistantand methicillin-susceptible Staphylococcus aureus is strain-<strong>de</strong>pen<strong>de</strong>nt. JPhotochem Photobiol B 90:57-63.15. Epstein J, San<strong>de</strong>rson IR, Macdonald TT (2010) Curcumin as a therapeuticagent: the evi<strong>de</strong>nce from in vitro, animal and human studies. Br J Nutr103:1545-1557.16. Martins CV, da Silva DL, Neres AT, Magalhães TF, Watanabe GA, ModoloLV et al (2009) Curcumin as a promising antifungal of clinical interest. JAntimicrob Chemother 63:337-339.17. Dahl TA, McGowan WM, Shand MA, Srinivasan VS (1989) Photokilling ofbacteria by the natural dye curcumin. Arch Microbiol 151:183-185.
18. Priyadarsini KI (2009) Photophysics, photochemistry and photobiology ofcurcumin: Studies from organic solutions, bio-mimetics and living cells.Journal of Photochemistry and Photobiology C: Photochemistry 10:81-95.19. Wang Y, Lu Z, Wu H, Lv F (2009) Study on the antibiotic activity ofmicrocapsule curcumin against foodborne pathogens. Int J Food Microbiol136:71-74.20. Haukvik T, Bruzell E, Kristensen S, Tønnesen HH (2009) Photokilling ofbacteria by curcumin in different aqueous preparations. Studies on curcuminand curcuminoids XXXVII. Pharmazie 64:666-673.21. Shen L, Jia HF, Zhang HY (2005) A TD-DFT study on triplet excited-stateproperties of curcumin and its implications in elucidating the photosensitizingmechanisms of the pigment. Chemical Physics Letters 409: 300–303.22. Tsai T, Yang YT, Wang TH, Chien HF, Chen CT (2009) Improvedphotodynamic inactivation of gram-positive bacteria using hematoporphyrinencapsulated in liposomes and micelles.Lasers Surg Med 41:316-322.23. Szpakowska M, Lasocki K, Grzybowski J, Graczyk A (2001) Photodynamicactivity of the haematoporphyrin <strong>de</strong>rivative with rutin and argininesubstituents (HpD-Rut(2)-Arg(2)) against Staphylococcus aureus andPseudomonas aeruginosa. Pharmacol Res 44:243-246.24. Dovigo LN, Pavarina AC, <strong>Ribeiro</strong> AP, Brunetti IL, Costa CA, Jacomassi DP,Bagnato VS, Kurachi C (2011) Investigation of the photodynamic effects ofcurcumin against Candida albicans. Photochem Photobiol 87:895-903.25. Esposito P, Varvara G, Caputi S, Perinetti G (2003) Catalase activity in humanhealthy and inflamed <strong>de</strong>ntal pulps. Int Endod J 36:599-603.26. Bruzell EM, Morisbak E, Tønnesen HH (2005) Studies on curcumin andcurcuminoids. XXIX. Photoinduced cytotoxicity of curcumin in selectedaqueous preparations. Photochem Photobiol Sci 4:523-530.
- Page 1: UNESP - UNIVERSIDADE ESTADUAL PAULI
- Page 4 and 5: Dados CurricularesAna Paula Dias Ri
- Page 6 and 7: Dedico este trabalho...Aos meus pai
- Page 8 and 9: Dedico este trabalho... Ao meu amor
- Page 10 and 11: Giampolo. Obrigada por me incentiva
- Page 12 and 13: À Lívia, Juliana, Fernanda Alves,
- Page 14 and 15: “Não basta ter belos sonhos para
- Page 16 and 17: Resumo
- Page 18 and 19: indicando que a membrana citoplasm
- Page 20 and 21: Abstract
- Page 22 and 23: using the different delivery system
- Page 24 and 25: 1 IntroduçãoA Terapia Fotodinâmi
- Page 26 and 27: hospitalares 48 . Sabe-se que a col
- Page 28 and 29: (Linn), conhecida como açafrão da
- Page 30 and 31: 2 Proposição
- Page 32 and 33: 3 Capítulos
- Page 34 and 35: Phototoxic effect of Curcumin on me
- Page 36 and 37: than non-resistant strains. At the
- Page 38 and 39: inactivation (5, 10, 20 μM) and th
- Page 40 and 41: concentrations (5 and 10 μM) signi
- Page 42 and 43: PS for photodynamic inactivation of
- Page 44 and 45: compared with the negative control
- Page 48 and 49: 27. Kurien BT, Scofield RH (2009) H
- Page 50 and 51: Figure 3: Graphic representation of
- Page 52 and 53: 3.2 Capítulo 2Photodynamic inactiv
- Page 54 and 55: IntroductionCandida albicans is a c
- Page 56 and 57: medium and increases the possibilit
- Page 58 and 59: The microorganism used in this stud
- Page 60 and 61: Estimation of membrane damage by fl
- Page 62 and 63: Statistical analysisFor the purpose
- Page 64 and 65: with damaged cytoplasmic membrane.
- Page 66 and 67: 7A). As observed for the free ClAlP
- Page 68 and 69: demonstrated in previous studies (2
- Page 70 and 71: In order to evaluate the possible e
- Page 72 and 73: fluorescence on hyphal forms than y
- Page 74 and 75: 7- Chatterjee, D. K., L. S. Fong an
- Page 76 and 77: 20- Dovigo, L.N., A. C. Pavarina, A
- Page 78 and 79: 33- Chandra, J., D. M. Kuhn, P. K.
- Page 80 and 81: FIGURES: Figure 1: Line graphic re
- Page 82 and 83: A B CFigure 5. A: Overview of a 33.
- Page 84 and 85: 3.3 Capítulo 3Antimicrobial photod
- Page 86 and 87: the highly reactive singlet oxygen
- Page 88 and 89: give a 600 mM stock solution. Befor
- Page 90 and 91: washed out. Aliquots of 150 μL of
- Page 92 and 93: control (p˂0.05); the other contro
- Page 94 and 95: ClAlPc or diluted in DMSO. On the o
- Page 96 and 97:
In addition to the photodynamic eff
- Page 98 and 99:
Authors Contribution:All authors ha
- Page 100 and 101:
Lambert PA (2002) Cellular impermea
- Page 102 and 103:
FiguresFigure 1. Line graphic repre
- Page 104 and 105:
Figure 5. Box-plot graphic represen
- Page 106 and 107:
4 DiscussãoA Terapia Fotodinâmica
- Page 108 and 109:
antibioticoterapia 80 . Entretanto,
- Page 110 and 111:
Sabe-se que o DMSO não representa
- Page 112 and 113:
como a membrana nuclear 19 . Dessa
- Page 114 and 115:
esultando em comportamento semelhan
- Page 116 and 117:
A investigação do efeito antimicr
- Page 118 and 119:
5 Conclusão
- Page 120 and 121:
as maiores doses de luz avaliadas.
- Page 122 and 123:
6 Referências ∗1. Allison RR, Mo
- Page 124 and 125:
22. Dovigo LN, Pavarina AC, Mima EG
- Page 126 and 127:
41. Kussovski V, Mantareva V, Angel
- Page 128 and 129:
59. Primo FL, Bentley MV, Tedesco A
- Page 130 and 131:
80. Tsai T, Yang YT, Wang TH, Chien
- Page 132 and 133:
7 ApêndiceNesta seção estão apr
- Page 134 and 135:
Tabela A1- Valores originais de ufc
- Page 136 and 137:
Tabela A7- Medidas de resumo, em lo
- Page 138 and 139:
B- Avaliação de diferentes concen
- Page 140 and 141:
Tabela A15- Sumário da Análise de
- Page 142 and 143:
Tabela A19- Sumário da Análise de
- Page 144 and 145:
Tabela A21- Valores originais de lo
- Page 146 and 147:
Tabela A24- Valores originais de ab
- Page 148 and 149:
Tabela A27- Valores originais obtid
- Page 150 and 151:
Tabela A28- Resultado das comparaç
- Page 152 and 153:
Testes foram realizados para verifi
- Page 154 and 155:
Tabela A33- Valores originais de lo
- Page 156 and 157:
Tabela A36- Resultado do teste de c
- Page 158 and 159:
Tabela A39- Valores originais de ab
- Page 160 and 161:
Tabela A43- Resultado do teste de c
- Page 162 and 163:
Tabela A46- Medidas de resumo de ab
- Page 164:
Autorizo a reprodução deste traba