Full text PDF (3.9MB) - Jurnalul de Chirurgie
Full text PDF (3.9MB) - Jurnalul de Chirurgie
Full text PDF (3.9MB) - Jurnalul de Chirurgie
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Articole Multimedia <strong>Jurnalul</strong> <strong>de</strong> <strong>Chirurgie</strong>, Iaşi, 2008, Vol. 4, Nr. 2 [ISSN 1584 – 9341]<br />
Parathyroid Carcinoma<br />
OUR EXPERIENCE<br />
Parathyroid Carcinoma<br />
Clinical Manifestations<br />
No differences between men and women!<br />
100<br />
90<br />
80<br />
70<br />
60<br />
50<br />
40<br />
30<br />
20<br />
10<br />
0%<br />
OUR EXPERIENCE<br />
A<strong>de</strong>noma<br />
Carcinoma<br />
Bone disease<br />
Renal disease<br />
Gastroenterological<br />
symptoms<br />
Neurologic symptoms<br />
Palpable neck mass<br />
12<br />
13<br />
Parathyroid Carcinoma<br />
Localizing<br />
Procedures<br />
OUR EXPERIENCE<br />
(23 cases)<br />
True positive<br />
False negative<br />
Ultrasonography 17/23 6/23<br />
Scintigraphy 99mTc/201Tl 9/10 1/10<br />
Scintigraphy 99mTc/MIBI 11/11 0/11<br />
CT scan 6/6 0/6<br />
MRI 2/2 0/2<br />
14<br />
Parathyroid Carcinoma<br />
Hystological<br />
Diagnosis of malignancy<br />
Uniform cellular pattern<br />
Mitotic figures<br />
Capsular and/or vascular invasion<br />
Schantz &<br />
Castleman 1973<br />
DNA in<strong>de</strong>x<br />
Nuclear enlargement<br />
Macronucleoli<br />
Immunoistochemical staining<br />
(RB protein, Ki-67)<br />
Jacobi 1989<br />
Shenton 1990<br />
San<strong>de</strong>lin 1992<br />
Cryns 1994<br />
Abbona 1995<br />
15<br />
Parathyroid Carcinoma<br />
Parathyroid Carcinoma<br />
Pathological Diagnosis:<br />
Additional markers<br />
Additional markers<br />
HRPT2<br />
Oncosuppressor gene<br />
PARAFIBROMIN<br />
(nuclear protein)<br />
Shattuk, NEJM 2003<br />
16<br />
17<br />
129
Change language