Full text PDF (3.9MB) - Jurnalul de Chirurgie
Full text PDF (3.9MB) - Jurnalul de Chirurgie
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Articole Multimedia <strong>Jurnalul</strong> <strong>de</strong> <strong>Chirurgie</strong>, Iaşi, 2008, Vol. 4, Nr. 2 [ISSN 1584 – 9341]<br />
Dec 2007<br />
HRPT2 mutations<br />
HPT-JT Syndrome<br />
Parathyroid A<strong>de</strong>noma<br />
(Parafibromin +)<br />
Parathyroid Carcinoma<br />
(15%)<br />
Parathyroid Carcinoma<br />
(Parafibromin -)<br />
Parathyroid Carcinoma<br />
Parathyroid Carcinoma<br />
Treatment<br />
Challenging diagnosis<br />
Capsular and vascular invasion (?)<br />
LOCAL RECURRENCES<br />
DISTANT METASTASES<br />
Control of hypercalcemia (acute HPT)<br />
Surgery<br />
Adjuvant therapies (?)<br />
Schantz & Castleman 1973<br />
18<br />
19<br />
Parathyroid Carcinoma<br />
Preoperative Treatment<br />
Parathyroid Carcinoma<br />
Palliative therapies:<br />
CINACALCET<br />
Saline infusion (4-6 6 L/die) + furosemi<strong>de</strong><br />
Bisphosphonates<br />
Clodronate (200-300 mg i.v. / 7 days)<br />
Etidronate (7.5 mg/kg / 3 hours x 3 days)<br />
Aledronate (20-40 mg/day)<br />
Pamidronate (60-90 mg i.v. . / 3-43<br />
4 days)<br />
Favia, , W J S 1998<br />
20<br />
Allosteric modulator of calcium-sensing<br />
receptor (CaR)<br />
Increasing CaR sensitivity to calcium<br />
PTH reduction<br />
serum Calcium and Phosphorus reduction<br />
Collins, JCEM 1998<br />
21<br />
130
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