Ghiduri practice hematologice - Spitalul Clinic Municipal de Urgenta ...
Ghiduri practice hematologice - Spitalul Clinic Municipal de Urgenta ...
Ghiduri practice hematologice - Spitalul Clinic Municipal de Urgenta ...
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TROMBOCITEMIA ESENTIALA<br />
Epi<strong>de</strong>miologie:<br />
Inci<strong>de</strong>nta: 2,38/100000/an<br />
Varsta medie: 50-60 ani<br />
Supravietuire: 10 ani la 64-80% din pacienti<br />
Tratament:<br />
- Pentru pacientii asimptomatici, fara risc aditional, < 60 ani sunt indicate “low<br />
dose” aspirina – 80-100 mg<br />
- Pentru pacientii simptomatici cu risc inalt cu antece<strong>de</strong>nte <strong>de</strong> tromboza sau/si<br />
hemoragic:<br />
o Citoreductie:<br />
Hidroxiuree – 15mg/kgc – scop Trombocite < 600000.<br />
Anagreli<strong>de</strong> – 4x0,5 mg/zi cu ajustarea dozei in functie <strong>de</strong> valoarea trombocitelor<br />
(trombocite < 450000-600000), dar nu mai mult <strong>de</strong> 10 mg/zi.<br />
Interferon alfa – 3x3 mil ui/saptamana<br />
Monitorizare HLG – initial saptamanal pana la stabilirea dozei optime, apoi la 3-4<br />
saptamani.<br />
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