Nr 6 2011 - Onkologi i Sverige
Nr 6 2011 - Onkologi i Sverige
Nr 6 2011 - Onkologi i Sverige
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••• kolorektal cancer<br />
Sammanfattningsvis kunde vi med<br />
utgångspunkt från en klinisk studie som<br />
undersökte effekten av strålbehandling<br />
visa att survivin, PINCH och lymfkärl<br />
var starkt kopplat till överlevnad hos<br />
ändtarmscancerpatienter. Den här informationen<br />
kan förhoppningsvis hjälpa oss<br />
i framtiden att förlänga överlevnaden för<br />
ändtarmscancerpatienter genom att välja<br />
ut de patienter som är bäst lämpade<br />
för strålbehandling.<br />
RefeRenslista<br />
1. Rödel F, Hoffmann J, Grabenbauer GG, et<br />
al. High survivin expression is associated<br />
with reduced apoptosis in rectal cancer and<br />
may predict disease free survival after preoperative<br />
radiochemotherapy and surgical<br />
resection. Stralenther Onkol 2002; 178:426-<br />
435.<br />
2. Rödel F, Hoffmann J, Distel L et al. Survivin<br />
as a radioresistant factor, and prognostic<br />
and therapeutic target for radiotherapy in<br />
rectal cancer. Cancer Res 2005; 11: 4881-<br />
4887.<br />
3. Ryan BM, ODonovan N, Duffy MJ. Survivin:<br />
A new target for anti-cancer therapy. Cancer<br />
Treat Rev 2009; 35: 553-562.<br />
30 onkologi i sverige nr 6– 11<br />
4. Rödel F, Frey B, Leitmann, et al. Survivin<br />
antisense oligonucleotides effectively radiosensitize<br />
colorectal cancer cells in both<br />
tissue culture and murine xenograft models.<br />
Int J Radiat Oncol Biol Phys 2008; 71:<br />
247-255.<br />
5. Zhang T, Otevrel T, Gao Z, et al. Evidence<br />
that APC regulates survivin expression: a<br />
possible mechanism contributing to the<br />
stem cell origin of colon cancer. Cancer Res<br />
2001; 61:8664-8667.<br />
6. Gianani R, Jarboe E, Orlicky D, et al. Expression<br />
of survivin in normal, hyperplastic,<br />
and neoplastic colonic mucosa. Hum Pathol<br />
2001; 32:119-125.<br />
7. Sarela AI, Scott N, Ramsdale J, et al. Immunohistochemical<br />
detection of the antiapoptosis<br />
protein, Survivin, predicts survival<br />
after curative resection of stage II colorectal<br />
carcinomas. Ann Surg Oncol 2001; 8:305-310.<br />
8. Gao J, Arbman G, Rearden A, Sun X-F: Stromal<br />
staining for PINCH is an independent<br />
prognostic indicator in colorectal cancer.<br />
Neoplasia 2004; 6:796-801.<br />
9. Eke I, Koch U, Hehlgans S, Sandfort V,<br />
Stanchi F, Zips D, Baumann M, Shevchenko<br />
A, Pilarsky C, Haase M, Baretton G, Calleja V,<br />
Larijani B, Fässler R, Cordes N: PINCH1 regulates<br />
Akt1 activation and enhances radioresistance<br />
by inhibiting PP1α. J Clin Invest<br />
2010; 120:2516-2527.<br />
10. Fukuda T, Chen K, Shi X, Wu C: PINCH-1<br />
is an obligate partner of integrin-linked kinase<br />
(ILK) functioning in cell shape modulation,<br />
motility, and survival. J Biol Chem 2003;<br />
278:51324-51333.<br />
11. Stoeltzing O, Liu W, Reinmuth N et al.<br />
Inhibition of integrin α5ß1 function with a<br />
small peptide (ANT-161) plus continous 5-Fu<br />
infusion reduces colorectal liver metastases<br />
and improves survival in mice. Int J cancer<br />
2003; 104: 496-503.<br />
12. Bono P, Wasenius VM, Heikkilä P et al.<br />
High LYVE-1-positive lymphatic vessel numbers<br />
are associated with poor outcome in<br />
breast cancer. Clin Cancer Res 2004; 10:<br />
7144-7149.<br />
13. Maula S, Luukkaa M, Grenman R et al. Intratumoral<br />
lymphatics are essential for the<br />
metastatic spread and prognosis in squamous<br />
cell carcinoma of the head and neck<br />
region. Cancer Res 2003; 63: 1920-1926.<br />
AnnicA Holmqvist, ST-läkare, OnkOlOgiSka kliniken, linköping univerSiTeTSSjukhuS, annika.hOlmqviST@liO.Se