Heft 2/2013 - DGE

36 | Preisverleihungen
non-significant trends for associations with higher
FSH and reduced testicular volumes. However, in the
combined model, FSHR 2039A>G significantly modulated
the more dominant effect of FSHB -211G>T on
serum FSH and testicular volume among the T-allele
carriers.
By analysing both SNPs for the first time, we convincingly
show that indeed FSHR 2039A>G has an effect
also in males. In the proposed model of the combined
effects, FSHB -211G>T acts strongly on male reproductive
parameters while the FSHR 2039A>G effects were
approximately 2 to 3 times smaller. Clinically this is of
importance because oligozoospermic patients carrying
unfavourable variants affecting FSH action may benefit
from FSH treatment.
Very recently, we could also show for the first time that
the FSHB -211G>T T-allele was associated with both
higher FSH (0.99 U/l per T-allele) and LH levels (1.30
U/l) and with reduced progesterone (-1.96 ng/ml) in
365 thoroughly characterised women with normal
menstrual cycle intervals and proven ovulation. Gender
specific mechanisms, probably involving progesterone
in females, may explain the partially opposing findings
concerning FSHB -211G>T.
In conclusion, the SNPs in the FSHB and FSHR genes
have significant impact on reproductive parameters in
both sexes and the combinatory effects of variants in
hormone and receptor are an unparalleled example in
endocrinology.
Tüttelmann F, Laan M, Grigorova M, Punab M, Sõber S, Gromoll J. Combined
Effects of the Variants FSHB -211G>T and FSHR 2039A>G on Male
Reproductive Parameters. J Clin Endocrinol Metab 97:3639-47 (2012)
Schüring AN, Busch AS, Bogdanova N, Gromoll J, Tüttelmann F. Effects
of the FSH-ß-subunit promoter polymorphism -211G>T on the hypothalamic-pituitary-ovarian
axis in normally cycling women indicate a
gender specific regulation of gonadotropin secretion. J Clin Endocrinol
Metab 98:E82-6 (2013)
Kurz-Lebenslauf
geboren 04. April 1975
Dr. med. Frank Tüttelmann
Institut für Humangenetik, Universität Münster
Vesaliusweg 12-14, 48149 Münster
frank.tuettelmann@ukmuenster.de
Ausbildung und Berufstätigkeit
2012 Anerkennung Facharzt für Humangenetik
2012– Vorstandsmitglied Deutsche Gesellschaft für Andrologie
2009– Mitglied der European Academy of Andrology
2008– Assistenzarzt/wiss. Mitarbeiter, Institut für Humangenetik, Universität
Münster
2006 Clinical Andrologist der European Academy of Andrology
2006 Promotion zum Dr. med. an der Medizinischen Fakultät der Universität Münster
2006– Gründer und Präsident des International Network for Young Researchers in Male Fertility
2004–2008 Assistenzarzt/wiss. Mitarbeiter, Institut für Reproduktionsmedizin, Universität Münster
2004 Approbation als Arzt
2003–2004 Arzt im Praktikum, Institut für Reproduktionsmedizin, Universität Münster
1995–2002 Studium der Humanmedizin, Ruhr-Universität Bochum
Awards
2013 Young Andrologist Award der International Society of Andrology
2012 Preis des Journal of Endocrinology (European Congress of Endocrinology)
2009 Clinical Research Award des IZKF Münster
2009 Forschungsstipendium der Deutschen Gesellschaft für Andrologie
Endokrinologie Informationen 37 (2013) 2