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ArzneimittelPROFIL Venetoclax 2019

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11. Literatur<br />

In der Online-Version sind die Links zur PubMed-Datenbank, zu Kongressabstracts<br />

sowie zum Studienregister verfügbar: www.arzneimittelprofil.at<br />

Anderson MA, Huang D, & Roberts A: Targeting BCL2 for the treatment of<br />

lymphoid malignancies; Semin Hematol 2014; 51: 219–227<br />

https://www.ncbi.nlm.nih.gov/pubmed/25048785<br />

Anderson MA, Deng J, Seymour JF, et al.: The BCL2 selective inhibitor<br />

venetoclax induces rapid onset apoptosis of CLL cells in patients via a<br />

TP53-independent mechanism; Blood 2016; 127: 3215–3224<br />

https://www.ncbi.nlm.nih.gov/pubmed/27069256<br />

Cimmino A, Calin GA, Fabbri M, et al.: miR-15 and miR-16 induce apoptosis<br />

by targeting BCL2; Proc Natl Acad Sci USA 2005; 102: 13944–13949<br />

https://www.ncbi.nlm.nih.gov/pubmed/16166262<br />

Cory S, Roberts AW, Colman PM, et al.: Targeting BCL-2-like proteins to kill<br />

cancer cells; Trends Cancer 2016; 2: 443–460<br />

https://www.ncbi.nlm.nih.gov/pubmed/28741496<br />

Coutre S, Choi M, Furman RR, et al.: <strong>Venetoclax</strong> for patients with chronic<br />

lymphocytic leukemia who progressed during or after idelalisib therapy;<br />

Blood 2018; 131: 1704–1711<br />

https://www.ncbi.nlm.nih.gov/pubmed/29305552<br />

Davids MS, Hallek M, Wierda W, et al.: Comprehensive safety analysis of<br />

<strong>Venetoclax</strong> monotherapy for patients with relapsed/refractory chronic<br />

lymphocytic leukemia; Clin Cancer Res 2018; 24: 4371–4379<br />

https://www.ncbi.nlm.nih.gov/pubmed/29895707<br />

Fachinformation <strong>Venetoclax</strong> (Venclyxto®); Stand 5.12.2018<br />

https://www.ema.europa.eu/<br />

Hallek M; German CLL Study Group: Prognostic factors in chronic<br />

lymphocytic leukemia; Ann Oncol 2008; 19 Suppl 4: iv51-3<br />

https://www.ncbi.nlm.nih.gov/pubmed/18519404<br />

Hallek M: Chronic lymphocytic leukemia: 2017 update on diagnosis, risk<br />

stratification, and treatment; Am J Hematol 2017; 92: 946–965<br />

https://www.ncbi.nlm.nih.gov/pubmed/28782884<br />

Jones JA, Mato AR, Wierda WG, et al.: <strong>Venetoclax</strong> for chronic lymphocytic<br />

leukaemia progressing after ibrutinib: an interim analysis of a multicentre,<br />

open-label, phase 2 trial; Lancet Oncol 2018; 19: 65–75<br />

https://www.ncbi.nlm.nih.gov/pubmed/29246803<br />

Kater AP, Seymour JF, Hillmen P, et al.: Fixed duration of <strong>Venetoclax</strong>-Rituximab<br />

in relapsed/refractory chronic lymphocytic leukemia eradicates<br />

minimal residual disease and prolongs survival: Post-treatment follow-up of<br />

the MURANO Phase III study; J Clin Oncol <strong>2019</strong>; 37: 269–277<br />

https://www.ncbi.nlm.nih.gov/pubmed/30523712<br />

Mato AR, Hill BT, Lamanna N, et al.: Optimal sequencing of ibrutinib,<br />

idelalisib, and venetoclax in chronic lymphocytic leukemia: results from a<br />

multicenter study of 683 patients; Ann Oncol 2017; 28: 1050–1056<br />

https://www.ncbi.nlm.nih.gov/pubmed/28453705<br />

Onkopedia Leitlinie CLL, 2017<br />

http://www.oegho.at/onkopedia-leitlinien/haematologische-neoplasien/<br />

chronische-lymphatische-leukaemie-cll.html<br />

Potter DS & Letai A: To prime, or not to prime: that is the question; Cold<br />

Spring Harb Symp Quant Biol 2016; 81: 131–140<br />

https://www.ncbi.nlm.nih.gov/pubmed/27811212<br />

Roberts, A.W. et al.: Substantial susceptibility of chronic lymphocytic<br />

leukemia to BCL2 inhibition: results of a phase I study of navitoclax in<br />

patients with relapsed or refractory disease; J Clin Oncol 2012; 30: 488-96<br />

https://www.ncbi.nlm.nih.gov/pubmed/22184378<br />

Roberts AW, Seymour JF, Brown JR, et al.: Targeting BCL2 with venetoclax in<br />

relapsed chronic lymphocytic leukemia; N Engl J Med 2016; 374: 311–322<br />

https://www.ncbi.nlm.nih.gov/pubmed/26639348<br />

Roberts AW & Huang D: Targeting BCL2 with BH3 mimetics: basic science<br />

and clinical application of venetoclax in chronic lymphocytic leukemia and<br />

related B cell malignancies; Clin Pharmacol Ther 2017; 101: 89–98<br />

https://www.ncbi.nlm.nih.gov/pubmed/27806433<br />

Rossi D, Rasi S, Spina V, et al.: Integrated mutational and cytogenetic<br />

analysis identifies new prognostic subgroups in chronic lymphocytic<br />

leukemia; Blood 2013; 121:1403–1412<br />

https://www.ncbi.nlm.nih.gov/pubmed/23243274<br />

Seymour JF, Ma S, Brander DM, et al.: <strong>Venetoclax</strong> plus rituximab in relapsed<br />

or refractory chronic lymphocytic leukaemia: a phase 1b study; Lancet<br />

Oncol 2017; 18: 230–240<br />

https://www.ncbi.nlm.nih.gov/pubmed/28089635<br />

Seymour JF, Kipps T, Eichhorst B, et al.: <strong>Venetoclax</strong>-Rituximab in relapsed or<br />

refractory chronic lymphocytic leukemia; N Engl J Med 2018; 378: 1107–1120<br />

https://www.ncbi.nlm.nih.gov/pubmed/29562156<br />

Souers AJ, Leverson JD, Boghaert ER, et al.: ABT-199, a potent and selective<br />

BCL-2 inhibitor, achieves antitumor activity while sparing platelets; Nat<br />

Med 2013; 19: 202–208<br />

https://www.ncbi.nlm.nih.gov/pubmed/23291630<br />

Stilgenbauer S, Eichhorst B, Schetelig J, et al.: <strong>Venetoclax</strong> in relapsed or<br />

refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre,<br />

open-label, phase 2 study; Lancet Oncol 2016; 17: 768–778<br />

https://www.ncbi.nlm.nih.gov/pubmed/29715056<br />

Stilgenbauer S, Eichhorst B, Schetelig J, et al.: <strong>Venetoclax</strong> for patients with<br />

chronic lymphocytic leukemia with 17p deletion: Results from the full<br />

population of a phase II pivotal trial; J Clin Oncol 2018; 36: 1973–1980<br />

https://www.ncbi.nlm.nih.gov/pubmed/29715056<br />

Thijssen R, Slinger E, Weller K, et al.: Resistance to ABT-199 induced by<br />

microenvironmental signals in chronic lymphocytic leukemia can be<br />

counteracted by CD20 antibodies or kinase inhibitors; Haematologica 2015;<br />

100: e302-6<br />

https://www.ncbi.nlm.nih.gov/pubmed/25957396<br />

14 <strong>ArzneimittelPROFIL</strong> <strong>Venetoclax</strong> April <strong>2019</strong>

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