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Antibiotic prophylaxis in surgery. (SIGN Guideline No 104)

Antibiotic prophylaxis in surgery. (SIGN Guideline No 104)

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<strong>Antibiotic</strong> prophylAxis <strong>in</strong> <strong>surgery</strong><br />

22<br />

Operation Recommendation Odds Ratio NNT Outcome Evidence level<br />

AbDomen<br />

urogenital<br />

D <strong>Antibiotic</strong> <strong>prophylaxis</strong> is not recommended 4 131<br />

transurethral resection of<br />

bladder tumours<br />

3 132<br />

Effectiveness is <strong>in</strong>ferred from evidence that<br />

SSI is high post-cystectomy<br />

radical cystectomy ; <strong>Antibiotic</strong> <strong>prophylaxis</strong> is recommended<br />

limb<br />

1 ++ ,1 + ,<br />

2 ++133,134,135,136<br />

Hip <strong>in</strong>fection<br />

Jo<strong>in</strong>t <strong>in</strong>fection<br />

42<br />

57<br />

0.27<br />

0.25<br />

b <strong>Antibiotic</strong> <strong>prophylaxis</strong> is highly recommended<br />

Arthroplasty<br />

++135, 136 2<br />

<strong>Antibiotic</strong>-loaded cement is recommended <strong>in</strong> addition to<br />

<strong>in</strong>travenous antibiotics<br />

b<br />

2 ++136<br />

up to 24 hours of antibiotic <strong>prophylaxis</strong> should be<br />

considered<br />

b<br />

open fracture A <strong>Antibiotic</strong> <strong>prophylaxis</strong> is highly recommended 0.41 14 Wound <strong>in</strong>fection 1 ++137<br />

open <strong>surgery</strong> for closed<br />

Deep wound<br />

A <strong>Antibiotic</strong> <strong>prophylaxis</strong> is highly recommended 0.36 38<br />

1<br />

fracture<br />

<strong>in</strong>fection<br />

++138<br />

Deep wound<br />

hip fracture A <strong>Antibiotic</strong> <strong>prophylaxis</strong> is highly recommended 0.55 23<br />

1<br />

<strong>in</strong>fection<br />

++139<br />

Effectiveness is <strong>in</strong>ferred from evidence<br />

about other clean-contam<strong>in</strong>ated procedures 475<br />

D <strong>Antibiotic</strong> <strong>prophylaxis</strong> is not recommended<br />

orthopaedic <strong>surgery</strong><br />

(without implant)<br />

lower limb amputation A <strong>Antibiotic</strong> <strong>prophylaxis</strong> is recommended 0.32 5 Wound <strong>in</strong>fection 1 +140

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