Milk Thistle: Effects on Liver Disease and Cirrhosis - Parents of Kids ...

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Adverse <strong>Effects</strong> of <strong>Milk</strong> <strong>Thistle</strong>...............................................................................................38 Overview of Adverse Effect Literature..............................................................................38 Common Symptomatic <strong>Effects</strong>..........................................................................................38 Common and Uncommon Serious Adverse <strong>Effects</strong> ..........................................................38 Chapter 4. Conclusions .................................................................................................................41 Chapter 5. Future Research...........................................................................................................43 Adverse <strong>Effects</strong>........................................................................................................................43 Beneficial <strong>Effects</strong> Regarding Liver Diseases ..........................................................................43 Specific Areas of Research ......................................................................................................43 References......................................................................................................................................45 Summary Tables ............................................................................................................................53 Evidence Tables ............................................................................................................................73 Bibliography ..................................................................................................................................99 Appendix A. <strong>Milk</strong> <strong>Thistle</strong> Search Strategies ..............................................................................113 Appendix B. Graphic Summaries ...............................................................................................115 Appendix C. Contributors...........................................................................................................143 Appendix D. Acronyms ..............................................................................................................149 viii
Appendix C. Contributors We owe a major debt of gratitude to the following groups of multidisciplinary experts from around the world who assisted in preparing this report: 10 national advisory panel members, 3 technical experts who helped define the scope and shape the content, 14 peer reviewers representing a variety of backgrounds and viewpoints, and 5 scientific authors who provided additional data from their studies. National Advisory Panel Marilyn Barrett, PhD Owner and Principal Pharmacognosy Consulting Services Mark Blumenthal Executive Director American Botanical Council David Eisenberg, MD Beth Israel Deaconess Medical Center Lucinda Miller, PharmD, BCPS Editor Journal of Herbal Pharmacotherapy Richard Nahin, MPH, PhD Acting Director Division of Extramural Research National Center for Complementary and Alternative Medicine Mary Ann Richardson, DrPH Assistant Professor and Director The University of Texas Center for Alternative Medicine Research in Cancer The University of Texas - Houston Health Science Center School of Public Health Nancy Ridenour, RN, PhD, CS, FNC, FAAN Dean College of Nursing Illinois State University David Schardt Associate Nutritionist Center for Science in the Public Interest 143
Page 1 and 2: Evidence Report/Technology Assessme
Page 3: Evidence Report/Technology Assessme
Page 7 and 8: Structured Abstract Objectives. Thi
Page 9: Contents Summary...................
Page 13 and 14: Wolfgang Fleig, MD Professor and Ch
Page 15: Project Investigators Valerie Lawre
Page 18 and 19: effectiveness were limited to place
Page 20 and 21: • Three trials evaluated milk thi
Page 23 and 24: Chapter 1. Introduction Scope and O
Page 25 and 26: The Plant Milk thi
Page 27 and 28: using over-the-counter “alternati
Page 29 and 30: controls. 41,42 Another study demon
Page 31 and 32: Figure 1. Evidence model: M
Page 33 and 34: Table 1. Key questions and selectio
Page 35 and 36: Table 2. Electronic sources searche
Page 37 and 38: Initially, we planned to limit effi
Page 39 and 40: Heterogeneity among trials was test
Page 41 and 42: Table 2. Electronic sources searche
Page 43 and 44: Chapter 3. Results Overview of the
Page 45 and 46: Among the 17 nonplacebo-controlled
Page 47 and 48: presented for cirrhotic patients in
Page 49 and 50: In the Phase II study, 60 subjects
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Page 57: apparent anaphylactoid reaction imp
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Table 3. Outcome measures and follo
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Table 4. Effect sizes and meta-anal
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Table 6. Effect sizes and meta-anal
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Chapter 5. Future Research Adverse
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References 1. Brown D. Silymarin ed
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41. Muzes G, Deak G, Lang I, et al.
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80. Kiesewetter E, Leodolter I, Tha
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Summary Table 1. Placebo-controlled
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Summary Table 8. Prophylactic milk
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Summary Table 10. Effect sizes and
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Summary Table 11. Effect sizes and
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Summary Table 12. Adverse effects o
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Evidence Table 1. Milk</str
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Blumenthal M (National Advisory Pan
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Fintelmann V. Zur Therapie der Fett
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Lang I, Deak G, Nekam K, et al. Hep
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Pifferi G. Silipide: A new bioavail
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Tittel G, Wagner H. High-performanc
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Appendix A. Milk <
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Z Statistic Effect Size -3.2 -1 2 0
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Feher 1990 Marcelli 1992 Trinchet 1
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Z Statistic -3.0 Buzelli 1993 2 0 -
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Feher 1990 Marcelli 1992 Palasciano
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Buzelli 1993 Fintelmann 1970 Fintel
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Feher 1990 Marcelli 1992 Combined E
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Buzelli 1993 Fintelmann 1970 Fintel
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Z Statistic Effect Size -1 2 0 -2 -
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Z Statistic -2 -2.2 Feher 1990 Trin
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Buzelli 1993 Fintelmann 1970 Magliu
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Z Statistic Effect Size 2.2 2 1 0.5
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Z Statistic -2.6 Feher 1990 Marcell
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Feher 1990 Marcelli 1992 Trinchet 1
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