Milk Thistle: Effects on Liver Disease and Cirrhosis - Parents of Kids ...

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Srini Srinivasan, PhD Director Dietary Supplements Division U.S. Pharmacopoeia Kathleen Stevens, RN, EdD, FAAN Professor Department of Family Nursing The University of Texas Health Science Center at San Antonio Wendell Winters, PhD Associate Professor Department of Microbiology The University of Texas Health Science Center at San Antonio Authors Who Provided Additional Data Some articles included in this report had relevant data missing from their publications. We contacted the authors requesting this information. Our heartfelt thanks to those who responded: Dr. Paolo Saba Dr. Heikki A. Salmi Dr. Gianluigi Vendemiale Dr. Peter Ferenci Dr. Robert Flisiak San Antonio Evidence-based Practice Center and Veterans Evidence-based Research, Dissemination and Implementation Center Staff Project Leaders Cynthia Mulrow, MD, MSc Program Director Valerie Lawrence, MD, MSc Principal Investigator 146
Project Investigators Valerie Lawrence, MD, MSc Cynthia Mulrow, MD, MSc Bradly Jacobs, MD, MPH Cathi Dennehy, PharmD Jodi Sapp, RN Christine Aguilar, MD, MPH Kelly Montgomery, MPH Laura Morbidoni, MD Elaine Chiquette, PharmD Kenneth Flora, MD, FACG Meta-Analysts Gilbert Ramirez, DrPH John E. Cornell, PhD Information Specialists Andrew Vickers, MD Martha Harris, MLS, MA Technical Writer and Peer Review Coordinator Jennifer Moore Arterburn, MTSC Computer Resources David Mullins Administration Annie Almanza Sheryl Moore Linn Morgan 147
Page 1 and 2: Evidence Report/Technology Assessme
Page 3: Evidence Report/Technology Assessme
Page 7 and 8: Structured Abstract Objectives. Thi
Page 9 and 10: Contents Summary...................
Page 11 and 12: Appendix C. Contributors We owe a m
Page 13: Wolfgang Fleig, MD Professor and Ch
Page 18 and 19: effectiveness were limited to place
Page 20 and 21: • Three trials evaluated milk thi
Page 23 and 24: Chapter 1. Introduction Scope and O
Page 25 and 26: The Plant Milk thi
Page 27 and 28: using over-the-counter “alternati
Page 29 and 30: controls. 41,42 Another study demon
Page 31 and 32: Figure 1. Evidence model: M
Page 33 and 34: Table 1. Key questions and selectio
Page 35 and 36: Table 2. Electronic sources searche
Page 37 and 38: Initially, we planned to limit effi
Page 39 and 40: Heterogeneity among trials was test
Page 41 and 42: Table 2. Electronic sources searche
Page 43 and 44: Chapter 3. Results Overview of the
Page 45 and 46: Among the 17 nonplacebo-controlled
Page 47 and 48: presented for cirrhotic patients in
Page 49 and 50: In the Phase II study, 60 subjects
Page 51 and 52: Insert Table 3 Here. 33
Page 57: apparent anaphylactoid reaction imp
Page 60 and 61: Table 3. Outcome measures and follo
Page 62 and 63: Table 4. Effect sizes and meta-anal
Page 64 and 65:
Table 6. Effect sizes and meta-anal
Page 67 and 68:
Chapter 5. Future Research Adverse
Page 69 and 70:
References 1. Brown D. Silymarin ed
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41. Muzes G, Deak G, Lang I, et al.
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80. Kiesewetter E, Leodolter I, Tha
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Summary Table 1. Placebo-controlled
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Summary Table 8. Prophylactic milk
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Summary Table 10. Effect sizes and
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Summary Table 11. Effect sizes and
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Summary Table 12. Adverse effects o
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Evidence Table 1. Milk</str
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Blumenthal M (National Advisory Pan
Page 121 and 122:
Fintelmann V. Zur Therapie der Fett
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Lang I, Deak G, Nekam K, et al. Hep
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Pifferi G. Silipide: A new bioavail
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Tittel G, Wagner H. High-performanc
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Appendix A. Milk <
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Z Statistic Effect Size -3.2 -1 2 0
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Feher 1990 Marcelli 1992 Trinchet 1
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Z Statistic -3.0 Buzelli 1993 2 0 -
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Feher 1990 Marcelli 1992 Palasciano
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Buzelli 1993 Fintelmann 1970 Fintel
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Feher 1990 Marcelli 1992 Combined E
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Buzelli 1993 Fintelmann 1970 Fintel
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Z Statistic Effect Size -1 2 0 -2 -
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Z Statistic -2 -2.2 Feher 1990 Trin
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Buzelli 1993 Fintelmann 1970 Magliu
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Z Statistic Effect Size 2.2 2 1 0.5
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Z Statistic -2.6 Feher 1990 Marcell
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Feher 1990 Marcelli 1992 Trinchet 1
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