Milk Thistle: Effects on Liver Disease and Cirrhosis - Parents of Kids ...

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On December 6, 1999, under Public Law 106-129, the Agency for Health Care Policy and Research (AHCPR) was reauthorized and renamed the Agency for Healthcare Research and Quality (AHRQ). The law authorizes AHRQ to continue its research on the cost, quality, and outcomes of health care and expands its role to improve patient safety and address medical errors. This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.
Evidence Report/Technology Assessment Number 21 <strong>Milk</strong> <strong>Thistle</strong>: <strong>Effects</strong> on Liver Disease and Cirrhosis and Clinical Adverse <strong>Effects</strong> Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 2101 East Jefferson Street Rockville, MD 20852 Contract No. 290-97-0012 Prepared by: San Antonio Evidence-based Practice Center based at The University of Texas Health Science Center at San Antonio and The Veterans Evidence-based Research, Dissemination, and Implementation Center, a Veterans Affairs Health Services Research and Development Center of Excellence Cynthia Mulrow, MD, MSc Program Director Valerie Lawrence, MD, MSc Principal Investigator Bradly Jacobs, MD, MPH Cathi Dennehy, PharmD Jodi Sapp, RN Gilbert Ramirez, DrPH Christine Aguilar, MD, MPH Kelly Montgomery, MPH Laura Morbidoni, MD Jennifer Moore Arterburn, MTSC Elaine Chiquette, PharmD Martha Harris, MLS, MA David Mullins Andrew Vickers, MD Kenneth Flora, MD, FACG AHRQ Publication No. 01-E025 October 2000
Page 1: Evidence Report/Technology Assessme
Page 7 and 8: Structured Abstract Objectives. Thi
Page 9 and 10: Contents Summary...................
Page 11 and 12: Appendix C. Contributors We owe a m
Page 13 and 14: Wolfgang Fleig, MD Professor and Ch
Page 15: Project Investigators Valerie Lawre
Page 18 and 19: effectiveness were limited to place
Page 20 and 21: • Three trials evaluated milk thi
Page 23 and 24: Chapter 1. Introduction Scope and O
Page 25 and 26: The Plant Milk thi
Page 27 and 28: using over-the-counter “alternati
Page 29 and 30: controls. 41,42 Another study demon
Page 31 and 32: Figure 1. Evidence model: M
Page 33 and 34: Table 1. Key questions and selectio
Page 35 and 36: Table 2. Electronic sources searche
Page 37 and 38: Initially, we planned to limit effi
Page 39 and 40: Heterogeneity among trials was test
Page 41 and 42: Table 2. Electronic sources searche
Page 43 and 44: Chapter 3. Results Overview of the
Page 45 and 46: Among the 17 nonplacebo-controlled
Page 47 and 48: presented for cirrhotic patients in
Page 49 and 50: In the Phase II study, 60 subjects
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Insert Table 4 Here. 35
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Insert Table 6 Here. 37
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apparent anaphylactoid reaction imp
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Table 3. Outcome measures and follo
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Table 4. Effect sizes and meta-anal
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Table 6. Effect sizes and meta-anal
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Chapter 5. Future Research Adverse
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References 1. Brown D. Silymarin ed
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41. Muzes G, Deak G, Lang I, et al.
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80. Kiesewetter E, Leodolter I, Tha
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Summary Table 1. Placebo-controlled
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Summary Table 8. Prophylactic milk
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Summary Table 10. Effect sizes and
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Summary Table 11. Effect sizes and
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Summary Table 12. Adverse effects o
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Evidence Table 1. Milk</str
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Blumenthal M (National Advisory Pan
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Fintelmann V. Zur Therapie der Fett
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Lang I, Deak G, Nekam K, et al. Hep
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Pifferi G. Silipide: A new bioavail
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Tittel G, Wagner H. High-performanc
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Appendix A. Milk <
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Z Statistic Effect Size -3.2 -1 2 0
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Feher 1990 Marcelli 1992 Trinchet 1
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Z Statistic -3.0 Buzelli 1993 2 0 -
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Feher 1990 Marcelli 1992 Palasciano
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Buzelli 1993 Fintelmann 1970 Fintel
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Feher 1990 Marcelli 1992 Combined E
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Buzelli 1993 Fintelmann 1970 Fintel
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Z Statistic Effect Size -1 2 0 -2 -
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Z Statistic -2 -2.2 Feher 1990 Trin
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Buzelli 1993 Fintelmann 1970 Magliu
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Z Statistic Effect Size 2.2 2 1 0.5
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Z Statistic -2.6 Feher 1990 Marcell
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Feher 1990 Marcelli 1992 Trinchet 1
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