Milk Thistle: Effects on Liver Disease and Cirrhosis - Parents of Kids ...

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William A. Watson, PharmD, DABAT, FAACT Professor (Clinical) and Managing Director Department of Surgery South Texas Poison Center The University of Texas Health Science Center at San Antonio Elizabeth Yetley, PhD Director Office of Special Nutritionals Center for Food Safety and Applied Nutrition Food and Drug Administration Technical Experts Bradly Jacobs, MD, MPH Senior Clinical Research Fellow Osher Center for Integrative Medicine Department of Medicine University of California - San Francisco/Veterans Affairs Medical Center Cathi Dennehy, PharmD Assistant Clinical Professor University of California at San Francisco Kenneth Flora, MD, FACG Assistant Professor Oregon Health Sciences University Peer Reviewers Fourteen peer reviewers provided insightful comments and feedback on our draft report. Maurizio Bonacini, MD Associate Professor Hepatitis Research Center Division of Gastroenterology and Liver Diseases Department of Medicine University of Southern California School of Medicine Robert Eckel, MD Professor Division of Endocrinology, Metabolism, and Diabetes Department of Medicine University of Colorado Health Science Center 144
Wolfgang Fleig, MD Professor and Chair First Department of Medicine Martin Luther University Halle-Wittenberg Halle (Saale), Germany Robert Fontana, MD Assistant Professor Department of Internal Medicine University of Michigan Health System Alexander Gerbes, MD Professor Ludwig-Maximilians-Universitat-München Eric Gershwin, MD Division Chief Division of Rheumatology/Allergy Department of Internal Medicine University of California at Davis School of Medicine Ruth Kava, PhD, RD Director of Nutrition American Council on Science and Health Ronald Koretz, MD Professor and Chief Division of Gastroenterology Department of Medicine University of California at Los Angeles David Lee, PhD Director Natural Products Laboratory McLean Hospital Klaus Linde, MD Researcher Centre for Complementary Medicine Research Department of Internal Medicine II Technichal University Tianshu Liu, MD, MSc Attending Physician Department of Gastroenterology Shanghai Medical University Zhoug Medical Hospital 145
Page 1 and 2: Evidence Report/Technology Assessme
Page 3: Evidence Report/Technology Assessme
Page 7 and 8: Structured Abstract Objectives. Thi
Page 9 and 10: Contents Summary...................
Page 11: Appendix C. Contributors We owe a m
Page 15: Project Investigators Valerie Lawre
Page 18 and 19: effectiveness were limited to place
Page 20 and 21: • Three trials evaluated milk thi
Page 23 and 24: Chapter 1. Introduction Scope and O
Page 25 and 26: The Plant Milk thi
Page 27 and 28: using over-the-counter “alternati
Page 29 and 30: controls. 41,42 Another study demon
Page 31 and 32: Figure 1. Evidence model: M
Page 33 and 34: Table 1. Key questions and selectio
Page 35 and 36: Table 2. Electronic sources searche
Page 37 and 38: Initially, we planned to limit effi
Page 39 and 40: Heterogeneity among trials was test
Page 41 and 42: Table 2. Electronic sources searche
Page 43 and 44: Chapter 3. Results Overview of the
Page 45 and 46: Among the 17 nonplacebo-controlled
Page 47 and 48: presented for cirrhotic patients in
Page 49 and 50: In the Phase II study, 60 subjects
Page 51 and 52: Insert Table 3 Here. 33
Page 57: apparent anaphylactoid reaction imp
Page 60 and 61: Table 3. Outcome measures and follo
Page 62 and 63:
Table 4. Effect sizes and meta-anal
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Table 6. Effect sizes and meta-anal
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Chapter 5. Future Research Adverse
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References 1. Brown D. Silymarin ed
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41. Muzes G, Deak G, Lang I, et al.
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80. Kiesewetter E, Leodolter I, Tha
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Summary Table 1. Placebo-controlled
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Summary Table 8. Prophylactic milk
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Summary Table 10. Effect sizes and
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Summary Table 11. Effect sizes and
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Summary Table 12. Adverse effects o
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Evidence Table 1. Milk</str
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Blumenthal M (National Advisory Pan
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Fintelmann V. Zur Therapie der Fett
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Lang I, Deak G, Nekam K, et al. Hep
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Pifferi G. Silipide: A new bioavail
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Tittel G, Wagner H. High-performanc
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Appendix A. Milk <
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Z Statistic Effect Size -3.2 -1 2 0
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Feher 1990 Marcelli 1992 Trinchet 1
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Z Statistic -3.0 Buzelli 1993 2 0 -
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Feher 1990 Marcelli 1992 Palasciano
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Buzelli 1993 Fintelmann 1970 Fintel
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Feher 1990 Marcelli 1992 Combined E
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Buzelli 1993 Fintelmann 1970 Fintel
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Z Statistic Effect Size -1 2 0 -2 -
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Z Statistic -2 -2.2 Feher 1990 Trin
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Buzelli 1993 Fintelmann 1970 Magliu
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Z Statistic Effect Size 2.2 2 1 0.5
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Z Statistic -2.6 Feher 1990 Marcell
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Feher 1990 Marcelli 1992 Trinchet 1
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