CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
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Ph.D. Thesis Abstract Contribution to cinchona alkaloids chemistry<br />
.<br />
To improve the yield of the ester synthesis, there were performed experiments in order to<br />
optimize the synthesis of ester 31. For this we studied the influence of the molar ratios of 1,2-<br />
aminoalcoolul: benzyl chloride 28 and 1,2-aminoalcool: TEA on the yield. In table 2.4 and figure<br />
2.4 there are presented the results obtained with the variation of 1,2-<br />
aminoalcool: benzoyl chloride moar ratio.<br />
Tabel 2.4. Influența raportului molar 1,2-aminoalcool:clorura de benzoil<br />
Nr.<br />
Exp.<br />
alcool Clorura de<br />
Tip<br />
Nr.moli<br />
(mmoli)<br />
benzoil<br />
(mmoli)<br />
18<br />
TEA<br />
(mmoli)<br />
Randament<br />
(%)<br />
1 QCD 1 1 2 62,3<br />
2 QCD 3 5 6 83,8<br />
3 QCD 1 2 2 85,1<br />
4 QCI 1 1 2 60,1<br />
5 QCI 3 5 6 84,5<br />
6 QCI 1 2 2 83,9<br />
Figura 2.4. Influence of molar ratio 1,2-aminoalcool: benzoyl chloride
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