CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY

Ph.D. Thesis Abstract Contribution to cinchona alkaloids chemistry
.
We obtain a product, cinchonidine,appearing as white crystals following the
quality requirements of international regulations in force, even as a pharmaceutical product. The
obtained results in the synthesis phase of cinchonidine, respectively its purification are
presented in Table. 2.9 and 2.10.
Nr
Nr.
Tabelul 2.9. Results obtained in the synthesis of cinconidine 4
MATERII PRIME Produşi
Alcool etilic
(ml)
Tartrat de
cinconidina
(g)
Soluţie
amoniac
25%
(ml)
26
Cinconidin
a (g)
Filtrat
(g)
1 900 256 60 111 1116 78,1
2 900 256 60 91 1060 83,6
3 900 300 90 109 1046 72,11
Tabelul 2.10. Results obtained in the purification phase of cinconidine 4
Materii prime Produşi
Cinconidina Acid
Cant
(g)
Conţ
(%)
sulfuric
30%
(g)
Hidroxid
de sodiu
10%
(g)
Apa
(ml)
Cinconidina
Purificata
(g)
Conţinut
Baze libere
(%)
Conţinut
1 111 78,1 136 433 2500 63 99,86 72,56
2 91 83,6 135 378 2259 55 99,94 72,23
3 120 72,11 193 600 2000 81 99.96 93,6
(%)
Randament
Following these processes we obtained cinchonidine with a purity from 99.86 to
99.96% with a yield ranging from 72-93%. If working in more concentrated solutions,
respectively a smaller amount of water in the reaction medium, yields are higher (93.6% ).
For quantitative assay of cinchona alkaloids there are recommended HPLC
methods with UVdetectors.
(%)