CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
CONTRIBUTION TO CINCHONA ALKALOIDS CHEMISTRY
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Ph.D. Thesis Abstract Contribution to cinchona alkaloids chemistry<br />
.<br />
During this experiments it was observed that when using a molar ratio<br />
QCD: BzCl = 1:1the yield has a value of only 62.3%, which is the lowest. When the molar ratio<br />
QCD:BzCl is 1:1,66 yield increases to 83%. If using a molar ratio QCD:BzCl of 1:2 we do not<br />
observe a significant increase in yield (85%). Based on the results (table 2.5, figure 2.5) we<br />
considered 1,2-aminoalcool: BzCl of 3:5 an optimal molar ratio. An increase in the molar ratio of<br />
1:2 is not economically optimal. Table 2.5 presents the influence of the 1,2-aminoalcohol:TEA<br />
ratio over the synthesis yield.<br />
Tabel 2.5. Influența raportului molar 1,2-aminoalcool:TEA<br />
Nr.<br />
Exp.<br />
Alcool Clorura de<br />
Tip<br />
Nr.moli<br />
(mmoli)<br />
benzoil<br />
(mmoli)<br />
19<br />
TEA<br />
(mmoli)<br />
Randament<br />
(%)<br />
1 QCD 1 1,66 1 53,6<br />
2 QCD 1 1,66 1,5 74,2<br />
3 QCD 1 1,66 2 83,8<br />
4 QCI 1 1,66 1 50,4<br />
5 QCI 1 1,66 1,5 77,1<br />
6 QCI 1 1,66 2 84,5<br />
Figura 2.5. Influența raportului molar 1,2-aminoalcool:TEA
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