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http://legacy.library.ucsf.edu/tid/fpe59c00/pdf 154 OSBAKKEN ET AL Idtion (state 4 to state 3 : inactive to aetire state . although since hean is always working, it is always in some sense in slate 3) and protein synthesis, which are compensatory mechanisms associated with more ehornic volume loading conditions If the work Iqad increased (} HR X SBP). there would be greater activation of oxidative phos . phorylation ; if work load did not change signigcantly. there would be no need for flhnher activation of oxidative phosphorylotion . It may be possible m use measurement of these phenomena in the following way to estimate the noetabolic reserve and/or viability of the hean under clinical conditions where changes in myocardial loading occur. Small changes in P,/PCr and/ar PCr/ATP ratios may indicate that there is considerable metabolic reserve and thus myocardial function 6s stable . Larger changes in these ratios may indicate that myocardial metabolism is strverdy tased and there is minimal metabolic rcsen•e, thus making myocardial function relatively tess stable. Fa,nher studies using J' P NMR techniques will be needed to rnore speciflplly suppon tlv.ese hypotheses . ACKNOWLEDGMENTS The wthnD7lunkluhn HaH18rDte and laek L
http://legacy.library.ucsf.edu/tid/fpe59c00/pdf VOLUME WADING EFfECFS ON THE HEART IISING "P NMR 155 23 . B. CIe+N[E . J. S. LEIDH . J. KENr. K. MCCVLLY . S. NIOIU, B J . CwDN . J. MARn, AND T. GIUHAM. Pmr. NaN. Aaed. Sci LSU 113, 9438 f 19161 26. H . L KANroR . R . W. BlaD6i K . MeTi AND R S BuAUN, Amn. J. Cardrot 231 (lJrort Cin PAI+IaJ. 20). H171 (19861 27. S, 1- Swtwnrs, E BuUNWwLD . G. R WEICH, 1N.. R- R CASE. W. K STnINCeV. AND R . MAC71vi. Amm^ J. PAISioA 19L 146 (1959) . 28. 1. KooANw A. WIInE . M. l. lAem D. DAODER, AND K. YAreADa. l. d/oL Cef/ CardiaL 16. 247 (1984 19. B. Hw1aNU.ro AND M. L Hcs.IACC 6I1 L 215 (19851 30 M. SN~. . P. F. KAat . U. V . WwDt.'s, AND M. M. KIasH . C~mfanar 66(1). 485 (1962) . 31. M . D. SfuN. A. 1.1. CHiEN, M . C. CArAOnOSA . D.1. PnTa AND E . C. Lucor7A. Cnr Bn. l6161. 699 (19851 . 32. T. NA~uaism H. H . Yot1ND . T . SxIN¢o. K . ND~NNxE. AND l. G1 . IAID~utwm. J A/d Ca•droJ 16 . 519419941 - !l. R. Aww. M . TANUnA. AND 1. TAMAZnN1. (1rc. 8e. 51448 (19AJ1. JI. I:. H . HDEEnMD. B. . 0 EmsaD~.l. KIEwnE/L R. MAvND,AND K.O . R06FN.Ana IkJSId. SnrtQ 11). 111981). 37. E G . Kwa[ AND A. WmacN11exDEA. Adr. Crr NvW. Bn. 12, y911980) . 36. P. V . HAn . K. RnN~N, P. Gasmm..U, M . LArut4, AND F. L7UilwuD. Barvr Rn Co.dlol 7S, 103 (1980). PArcATroNs 028404 10347661
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