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150 OSB{KKEx ET AL
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w
Cot 1 Cot 3
aul R ^ p"^ " " 4eRRSgCRRSPGg ^_
~rcggcgY°- v ~_ t
~ s ti r L r ` t Y
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http://legacy.library.ucsf.edu/tid/fpe59c00/pdf
Cot 4
An
-/L
Cot 5 ~a Cot 6
e P./PCr ,
• PCr/0.TP
Cot7 nleRwSBP
- ~ccccxsrcas =f - F .^ asa stffc }
FlG. 5 . Metabolic and meAunrral respnmrs to araje anenal-trnout shunts L41'SI in sr .en pn. Data
tle pesented as pr+KnLigt changt from cnntrul (Su Y, J. 3- and 6 genenllv had an mctrase ,n HR x SBP
during rmpoutlon of thunr tondmonf Cars 2 . l and 7 genrmlh had a dernaac m HR x SBP dunng
impovuon nf .hunt eondniom The meut+obc pnameten IP,/PCr and PL-r/ATPI Parallel rhanges on mt .
duniul panmeten tHR x SRPI: that is, am mivease in HR N SBr,canmmed .nlh am mmase in P{PCr
end d.ertase in PCr/ATP nuos A derrease in HR x SBP is generally auwnaud ..iM a sl,ght ,nneau .
drnrate. on rw change tn O,/P('r arM a 9rgln derrtau, mrrease, or no change on PCR!ATP ranos . P, .
Inorgamr phosphate: PCr. phouphoc¢aone: ATP, denoune ttiphmPhn2 HR. hean ratr. and SBP-slxobr
blood pnssure .
HR x SBP relationship appeared to be quite stable : i.e. . there was minimal change in
P/PCr for any change in the HR x SOP (Fig . 6) . The PCr/ATP vs HR x SOP r41ationship
also appeared to be quite stable . with very little change in PCr/ATP with a
change in HR x SBP (Fig. 7/.
Evaluation of comMned cat data . for the entire volume loading time . demonslrated
that PCr/ATP almosl always decreased (even if the decrease oas sometimes small)
after opening of the AV shums. regardless of the HR x SBP /esponse (Fig . 8). In
addition. P,/PCr generally increased in conjunction with a decrease in PCr/ATP for
all points of time throughout acu7e volume loading (Rg . 9) . When changes in P,/f°Cr
were eorrelated with changes in HR x SBP for all points in time for the entire grolap .
there appeared to be a trend towald linearity (Fig . 10) t+'ith P,/PCr increasing as 11R
x SOP increased .
DISiL351O.`t
There are a number of hypotheses concerning the tissue events which may lead In
myroeardial eell damage and/or death (-'8--i1): ischemia . hypoxia . acidemia. oxygen
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