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~ 150 OSB{KKEx ET AL r w Cot 1 Cot 3 aul R ^ p"^ " " 4eRRSgCRRSPGg ^_ ~rcggcgY°- v ~_ t ~ s ti r L r ` t Y 1 .] 1 Co12 ••4qy.1 : 6~~CR^n$a[ir$ 9 http://legacy.library.ucsf.edu/tid/fpe59c00/pdf Cot 4 An -/L Cot 5 ~a Cot 6 e P./PCr , • PCr/0.TP Cot7 nleRwSBP - ~ccccxsrcas =f - F .^ asa stffc } FlG. 5 . Metabolic and meAunrral respnmrs to araje anenal-trnout shunts L41'SI in sr .en pn. Data tle pesented as pr+KnLigt changt from cnntrul (Su Y, J. 3- and 6 genenllv had an mctrase ,n HR x SBP during rmpoutlon of thunr tondmonf Cars 2 . l and 7 genrmlh had a dernaac m HR x SBP dunng impovuon nf .hunt eondniom The meut+obc pnameten IP,/PCr and PL-r/ATPI Parallel rhanges on mt . duniul panmeten tHR x SRPI: that is, am mivease in HR N SBr,canmmed .nlh am mmase in P{PCr end d.ertase in PCr/ATP nuos A derrease in HR x SBP is generally auwnaud ..iM a sl,ght ,nneau . drnrate. on rw change tn O,/P('r arM a 9rgln derrtau, mrrease, or no change on PCR!ATP ranos . P, . Inorgamr phosphate: PCr. phouphoc¢aone: ATP, denoune ttiphmPhn2 HR. hean ratr. and SBP-slxobr blood pnssure . HR x SBP relationship appeared to be quite stable : i.e. . there was minimal change in P/PCr for any change in the HR x SOP (Fig . 6) . The PCr/ATP vs HR x SOP r41ationship also appeared to be quite stable . with very little change in PCr/ATP with a change in HR x SBP (Fig. 7/. Evaluation of comMned cat data . for the entire volume loading time . demonslrated that PCr/ATP almosl always decreased (even if the decrease oas sometimes small) after opening of the AV shums. regardless of the HR x SBP /esponse (Fig . 8). In addition. P,/PCr generally increased in conjunction with a decrease in PCr/ATP for all points of time throughout acu7e volume loading (Rg . 9) . When changes in P,/f°Cr were eorrelated with changes in HR x SBP for all points in time for the entire grolap . there appeared to be a trend towald linearity (Fig . 10) t+'ith P,/PCr increasing as 11R x SOP increased . DISiL351O.`t There are a number of hypotheses concerning the tissue events which may lead In myroeardial eell damage and/or death (-'8--i1): ischemia . hypoxia . acidemia. oxygen PUBLICATIQNS 10347656 I 028399
® 0 VOLUME LOADING EFFFCfS ON THE HEART USING 'P Nh/R a .,cm L-r > • i cnr S cm h ,Cm s • ~r t a .~ ` a ~:;~ • s T .~~~•rrs • • or . a e w r• a ~o r• a s w ..e . frcc mdicals. abnomlal calcium metabolism, lactate accumulation . pusrinsult Vascular changea, and possibly bioencrgetic changes. There have been many inveatigations tonmrning the eBccts of ischemia and/or h,vpoxia on energv metabolism of dte hean . h ~ is now known that both of thesr conditions are associated aith changes in oxidative phosphorylation (dd-33). Although much is understood about rhe ellects of these stresses on energy metabolism. less is known about the'etTecl of other types of stress . . http://legacy.library.ucsf.edu/tid/fpe59c00/pdf ~ a . •• e m r a m • e eo ~ r . r e ~o o s Cor 2 6ar n Cnr 7 Flc. 6. forrelaron of HR X SBP rirh P,IPCr fou se.en sau durins acme aruriol-nnom shunung . Note auu t
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