Biodentine

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At the entrance of the dentine tubules, some mineral re-crystallisation occurs, creating mineral tags. This induces micromechanical anchorage of Biodentine. This process will continue with time, improving the sealing. Pr Colon, Dr Pradelle Comparison of the interface between Biodentine or Fuji II LC and a composite, using Optibond ® Solo Plus: The interfaces are very similar. Pr Dejou, Dr Raskin Perfect seal of Biodentine in contact with radicular dentine, as well as between two increments of Biodentine, in an in vitro test of apexification. Dr Bronnec, Pr Colon Crystallisation process in the dentine tubule of an extracted wisdom tooth treated with Biodentine, observed after 28 days of storage in distilled water. The dentine tubules are obturated by recrystallisation. Dr Franquin 19
20 ❹ Outstanding biocompatibility From a regulatory point of view, Biodentine is a calcium silicate based material, used for crown and root dentine repair treatment, involving external contact for a period of more than 30 days. The biocompatibility tests required for the preclinical evaluation of dental products followed the guideline ISO 7405 - 2008. The following sections evaluate the compliance with this standard for the tests carried out on Biodentine. It is considered a device with external contact, for long-term tissue contact (>30 days). In certain indications (radicular, apical obstruction and repair of the pulpal floor), it can be considered an implanted system, according to the ISO classification. All biocompatibility tests were carried out on the final product Biodentine. 4.1 - Cytotoxicity tests (ISO 7405, ISO 10993-5) Different cytotoxicity tests carried out on Biodentine are reported. The first study was performed on human pulpal fibroblasts (human wisdom tooth), comparing Biodentine, calcium hydroxide and MTA (Dycal ® , Dentsply and ProRoot ® MTA Dentsply). The cell viability was determined by MTT incorporation (About, 2003b). Results showed Biodentine was non cytotoxic like MTA, whereas the undiluted cement Dycal ® induced 22 % of cytotoxicity (Table. 1). Product Cell death (%) Biodentine 0±8 MTA 0±9 CaOH 22±10 Table 1. Cell death after Dycal ® , MTA and BIODENTINE contact. Control Biodentine (4 weeks) MTA (4 weeks) Collagen DSP Moreover, the cell differentiation was evaluated with the expression of collagen, dentine sialoprotein (DSP) and osteonectin (OSN). Results showed the expression of the differentiation markers, underlining the safety of Biodentine (Fig. 8). Figure 8. Expression of collagen and dentine sialoprotein (DSP) after contact with Biodentine and MTA during 4 weeks.
Page 1 and 2: R&D Department Biodentine Active B
Page 3 and 4: 4 Introduction Biodentine was devel
Page 5 and 6: 6 1.1 - Setting reaction The calciu
Page 7 and 8: 8 ❷ Physico-chemical 2.1 - Settin
Page 9 and 10: 10 2.2 - Density and Porosity The m
Page 11 and 12: 12 (O’Brien 2008)). This maturati
Page 13 and 14: 14 ❸ The quality and durability o
Page 15 and 16: 16 3.2 - Resistance to microleakage
Page 17: 6 18 Z 250 Optibond Solo+ Biodentin
Page 21 and 22: 22 4.3 - Genotoxicity tests (ISO 74
Page 23 and 24: 24 ❺ Evidence based bioactivity T
Page 25 and 26: 26 The inflammatory process had dis
Page 27 and 28: 28 To conclude, Biodentine enhances
Page 29 and 30: 30 During the follow-up, the restor
Page 31 and 32: 32 6.3 - Biodentine is used as an e

Biodentine

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