Biodentine

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❶ Septodont’s initial objective was to develop a material based on the most biocompatible chemistry available for dental materials: calcium silicates, which can set in the presence of water. Although recognized as highly biocompatible and bioactive, all these materials lack reactivity, with very long setting times (more than 2 hours), low mechanical properties and with very difficult handling (depending on the water ratio, from a sandy consistency to a fluid paste). In order to take up the technological challenge of combining this calcium silicate chemistry with the requirements of a formulation compatible with classical restorative and endodontic practice, Septodont developed a new technological platform called Active Biosilicate Technology. This consists in controlling every step of the material formulation beginning with the purity of the raw materials. Usual dental calcium silicate cements are based on the “Portland Cement” materials, which result from the clinker products manufactured by the building industry from natural stone treatment. This implies that all these products inherently contain unpurifiable mixtures of calcium silicates (C 3 S + C 2 S), calcium aluminates (C 3 A), calcium aluminoferrites (C 4 AF), calcium sulfates (CaSO 4 - gypsum), together with low concentrations of metallic impurities coming from the natural minerals used as raw materials. The only way to reach our objectives in terms of purity control, high mechanical strength and short setting times, was to synthesize our own calcium silicate product. The Active Biosilicate Technology is a proprietary technology developed according to our state-of-the-art pharmaceutical background applied to the high temperate ceramic mineral chemistry. Septodont is now able to ensure the purity of the calcium silicate content of the formulation and the absence of any aluminate and calcium sulfate in the final product. Firing Active Biosilicate Technology Grinding Ground powder Biodentine capsule 5
6 1.1 - Setting reaction The calcium silicate has the ability to interact with water leading to the setting and hardening of the cement. This is a hydration of the tricalcium silicate (3CaO.SiO2 = C3S) which produces a hydrated calcium silicate gel (CSH gel) and calcium hydroxide (Ca (OH)2). 2(3CaO.SiO2) + 6H2O 3CaO.2SiO2.3H2O + 3Ca(OH) 2 C3S CSH This dissolution process occurs at the surface of each grain of calcium silicate. The hydrated calcium silicate gel and the excess of calcium hydroxide tend to precipitate at the surface of the particles and in the pores of the powder, due to saturation of the medium. This precipitation process is reinforced in systems with low water content. CSH CaOH 2- H SiO 2 4 Ca2+ O H 2 Biodentine Particle H 2 O The unreacted tricalcium silicate grains are surrounded by layers of calcium silicate hydrated gel, which are relatively impermeable to water, thereby slowing down the effects of further reactions. The C-S-H gel formation is due to the permanent hydration of the tricalcium silicate, which gradually fills in the spaces between the tricalcium silicate grains. The hardening process results from of the formation of crystals that are deposited in a supersaturated solution. Powder before hydration Deposition of CSH Biodentine after setting
Page 1 and 2: R&D Department Biodentine Active B
Page 3: 4 Introduction Biodentine was devel
Page 7 and 8: 8 ❷ Physico-chemical 2.1 - Settin
Page 9 and 10: 10 2.2 - Density and Porosity The m
Page 11 and 12: 12 (O’Brien 2008)). This maturati
Page 13 and 14: 14 ❸ The quality and durability o
Page 15 and 16: 16 3.2 - Resistance to microleakage
Page 17 and 18: 6 18 Z 250 Optibond Solo+ Biodentin
Page 19 and 20: 20 ❹ Outstanding biocompatibility
Page 21 and 22: 22 4.3 - Genotoxicity tests (ISO 74
Page 23 and 24: 24 ❺ Evidence based bioactivity T
Page 25 and 26: 26 The inflammatory process had dis
Page 27 and 28: 28 To conclude, Biodentine enhances
Page 29 and 30: 30 During the follow-up, the restor
Page 31 and 32: 32 6.3 - Biodentine is used as an e

Biodentine

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