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Dr. Roni Kasher<br />

Peptides & Polymers<br />

40 BGU NOW<br />

T<br />

he Land of Israel claims the<br />

world’s first water purification<br />

scheme: after our ancestors fled<br />

Egypt, they were thirsty, but found<br />

the water at Mara too bitter to drink.<br />

According to the Bible, Moses solved<br />

the problem by throwing a tree into<br />

the water, which instantly made it<br />

sweet.<br />

The process of creating potable<br />

water has never been so simple or<br />

so cheap.<br />

The good news is that relief is on<br />

the horizon: Dr. Roni Kasher, who<br />

recently joined BGU, will open a<br />

new laboratory in the Department<br />

of Water Desalination and Treatment<br />

at the Zuckerberg Institute for Water<br />

Research of the Jacob Blaustein<br />

Institutes for Desert Research in Sede<br />

Boqer. His plan? To design a new<br />

water purification membrane, an<br />

innovation that will benefit not only<br />

Israel, but also countries facing acute<br />

water shortages around the world.<br />

If ever a man came tailor-made<br />

for the job, Kasher is it. Born 42 years<br />

ago in Hawaii to Israeli parents, he<br />

has spent the last 15 years<br />

researching and working in organic<br />

chemistry, specifically with peptides<br />

and polymers, substances likely to<br />

figure in tomorrow’s more efficient<br />

water facilities. In every previous<br />

field of endeavor, Kasher focused<br />

on some aspect of peptide design<br />

and operation: he has a Ph.D. in<br />

organic chemistry from the Hebrew<br />

University of Jerusalem; for postdoctoral<br />

work, he opted for the<br />

laboratory of the former President<br />

of Israel, Prof. Ephraim Katzir, a<br />

pioneer in proteins and biopolymers.<br />

Back in 1948, Katzir<br />

established one of the first research<br />

facilities in the world in this field at<br />

the Weizmann Institute of Science.<br />

After his time at the Weizmann<br />

Institute, Kasher spent three years<br />

working on projects designed to<br />

eradicate organic pollutants in<br />

Israel’s coastal aquifer.<br />

Through it all, Kasher’s focus has<br />

involved peptides – what they are,<br />

how they work and what they can<br />

be designed to do.<br />

“Peptides are small fragments of<br />

proteins,” Kasher explains. “They<br />

are composed of the same building<br />

blocks as proteins – the amino acids<br />

– but peptides sometimes have<br />

biological functions that are very<br />

different. They can be either natural<br />

or synthetic, and because of their<br />

unique properties, they may hold<br />

the key to creating more efficient<br />

water treatment options than are<br />

now available. Today, removing<br />

A specifically designed anti-microbial<br />

peptide, which could bind with the thin film,<br />

would represent a serious breakthrough<br />

salt from either seawater or<br />

groundwater is accomplished by<br />

reverse osmosis (RO), which utilizes<br />

synthetic polymer membranes as a<br />

kind of filter. Since polymers are<br />

related to peptides and proteins, a<br />

more creative use of peptides might<br />

well represent a breakthrough in<br />

water treatment.”<br />

Reverse osmosis had its origins<br />

in Florida in the 1950s, when a<br />

process called “surface skimming”<br />

was developed. Salt water was<br />

passed over a membrane – a plastic<br />

divider – and fresh water would fall<br />

through, leaving the salts behind. In<br />

the 1960s, the term “reverse<br />

osmosis” was coined when the<br />

process was enhanced by using a<br />

pump to apply pressure to the salt<br />

water to force it through the<br />

membrane.Normally, if salt and<br />

fresh water exist on two sides of a<br />

membrane, the fresh water will filter<br />

into the salt side. By applying<br />

pressure to force the flow to run in<br />

the opposite direction, reverse<br />

osmosis occurs. Fresh water is<br />

extracted from salt water.<br />

“Israel is chronically short of<br />

sweet water,” Kasher says. “We need<br />

to be able to purify our resources in<br />

both our underground aquifers and<br />

the Mediterranean. If we can<br />

desalinate, we’ll have an abundant<br />

supply. In Israel, we understand<br />

how serious a shortage of drinking<br />

water would be.”<br />

Internationally, Israel has led the<br />

way in water treatment programs.<br />

In the 1980s, in Eilat, a commercial<br />

RO plant was established to<br />

desalinate brackish groundwater. In<br />

August 2005, a new state-of-the-art<br />

RO plant opened in Ashkelon,<br />

representing the first of several<br />

large-scale seawater desalination<br />

facilities in some stage of<br />

development.When fully<br />

operational, the Ashkelon plant will<br />

provide about 15 percent of Israel’s<br />

domestic water.<br />

Kasher’s commitment is to<br />

enhance and improve the efficiency

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