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Gram-negative facultative anaerobic rods

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Enterobacteriaceae: Antibiotic<br />

resistance<br />

Most frequently used agents:<br />

- Cephalosporins<br />

- carbapenems<br />

- aminoglycosides<br />

- fluoroquinolones<br />

Most important mechanisms of resistance<br />

- Production of β-lactamase<br />

- Efflux systems<br />

- Alteration of membrane proteins<br />

- Production of modifying enzymes<br />

- Mutations in target molecules<br />

2006. 03. 06.

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