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Gram-negative facultative anaerobic rods

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β-lactamase enzymes<br />

The most important types of β-lactamases:<br />

- extended-spectrum β-lactamases (ESBLs): klebsiella, E. coli<br />

- genes located on plasmids (easily transmit)<br />

- confers resistance against penicillins and most<br />

cephalosporins<br />

- metallo-β-lactamases (MBLs): klebsiella, pseudomonas<br />

- genes are located on plasmids or on the chromosome<br />

- confer resistance against all β-lactam antibiotics<br />

including carbapenems

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