3.30 MB - Academy of Medicine of Malaysia

MANAGEMENT OF HIV INFECTION IN CHILDREN
Guidelines for the Use of Antiretroviral Agents in HIV-1 Infected Adults &
Adolescents (October 2006), American Academy of Pediatrics and
Canadian Pediatric Society Guideline on the evaluation and treatment of the
human immunodeficiency virus -1 -exposed infant (2004), National Institutes
of Health Guidelines for the use of Antiretroviral Agents in Pediatric HIV
infection (2006 & 2008), Royal College of Obstetricians & Gynaecologists
Guideline On Management Of HIV In Pregnancy (2004), Guideline by the
Canadian HIV Trials Network Working Group on Vertical HIV Transmission
(2003) and WHO Guidelines Antiretroviral Therapy Of HIV Infection In
Infants And Children In Resource Limited Settings: Towards Universal
Access (2006), British HIV Association (BHIVA) Guidelines 2005, WHO
Guidelines For HIV Drug Resistance Surveillance In Newly Diagnosed And
Treatment-Naïve HIV Infected Subjects (2003). This guideline is based
largely on the findings of systematic reviews and meta-analyses in the
literature.
The evidence in the articles were graded using the modified version of those
used by the Catalonia Agency for Health Technology Assessment and
Research (CAHTAR) Spain, while the grading of recommendations in these
guidelines was modified from the Scottish Intercollegiate Guidelines
Network (SIGN). (Refer to inside back cover).
The clinical questions were divided into major subgroups and members of
the development group were assigned individual topics within these
subgroups. The group members met a total of twenty three times throughout
the development of the guideline. All literature retrieved were appraised by
individual members and presented in the form of evidence tables
and discussed during group meetings. All statements and recommendations
formulated were agreed by both the development group and review
committees. Where the evidence was insufficient the recommendations
were derived by consensus of the development group and review committees.
The draft guideline was posted on both the Ministry of Health Malaysia and
Academy of Medicine, Malaysia websites for comment and feedback. This
guideline has also been presented to the Technical Advisory Committee for
Clinical Practice Guidelines, and the Health Technology Assessment and
Clinical Practice Guidelines Council, Ministry of Health Malaysia for review
and approval.
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