(GISTs), in

GIST: overview and
molecular biology
* protooncogene c - Kit encodes
transmembrane tyrosine kinase
receptor located on long arm of
chr 4 (4q11 - q12);
A) dimerization and activation of
normal c - Kit receptor by its
ligand stem - cell factor;
B) in gastrointestinal stromal
tumors (GISTs), in - frame
deletions and point mutations in c
- Kit produce ligand - independent
constitutive activation of c - Kit;
[platelet derived growth factor α
(PDGFα) receptor operational in
pathogenesis of GISTs and
dermatofibrosarcoma
protuberans]
ATP, adenosine triphosphate; ADP,
adenosine diphosphate; P, phosphate.