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% of total<br />
IMATINIB TARGETS IN SOLID TUMORS. XVI.<br />
KIT MUTATION LOCATION PREDICTS<br />
IMATINIB MESYLATE RESPONSIVENESS<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
KIT Exon 11<br />
(n = 85)<br />
KIT Exon 9<br />
(n = 23)<br />
no mutation<br />
(n = 9)<br />
* KIT mutations predictive of response to<br />
imat<strong>in</strong>ib mesylate;<br />
* best response with exon 11 mutations<br />
PD<br />
SD<br />
PR<br />
Blanke et al ASCO 2004 Gastro<strong>in</strong>test<strong>in</strong>al Cancers Symposium, abs 2
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