CHARACTERIZATION OF PARASITE ANTIGENS ... - PAHO/WHO

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The collagenase from the Clostridium and the collagenase-like
extract from the cuticle of A. lumbricoides killed dogs with an
anaphylactoid reaction and both caused similar histopathology
as seen at autopsy.
Insight into the antigenic nature of sonie parasitic materials
has been derived by inference and not by direct isolation and
characterization. Another example of an antigen shared between
a helminth and a micro-organism is the relationship between
Trichinella spiralis and Salmonella typhi (124, 125). Since the
antigenic configuration of Salmonella species is known, various
Salmonella were reacted with an anti-trichinella serum in an
agglutination test. The major cross-reacting antigens involved
in these agglutination tests were the somatic 12 antigen of
Salmonella with a secondary role for the somatic 9 antigen. The
somatic 12 Salmonella antigen successfully immunized mice and
rats against experimental infection with larvae of T. spiralis.
The somatic 12 antigen of S. typhi has been characterized as
having molecules of carbohydrate, one terminating in glucose and
the second in rhamnose (71).
Another instance of cross-reactivity between Ascaris and
pneumococcus (iplooccus pneumoniae) was described by Heidelberg
et al. (45) Glycogen of Ascaris is thought to be closely related
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