sbornik_s_2011.pdf

XI. Workshop of Physical Chemists and Electrochemists´11 Brno
ANATOMICAL STUDY OF
PHARMACEUTICALLY IMPORTANT PLANT
MACLURA POMIFERA (RAF.) C.K. SCHNEID.
(MORACEAE)
Petr BABULA 1 , Jana TKADLEČKOVÁ 1 , Vojtěch ADAM 2 , René KIZEK 2
1 Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences
Brno, Palackeho 1/3, CZ-61242 Brno, Czech Republic.
2 Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University, Zemedelska 1, CZ-
61300 Brno, Czech Republic
Abstract
Maclura pomifera (Raf.) C.K.Schneid. (Moraceae), “Osage orange”, is the tree native to the
mid-western and south-eastern United States. Plant contains many different secondary
metabolites with interesting pharmaceutical properties, such as flavonoids, isoflavonoids,
triterpenes, xanthones and stilbenes. Despite the fact that plant is in the focus of interest
due to above-mentioned compounds, anatomical study of this plant is still missing. This
study is focused on the demonstration of anatomy of vegetative organs – roots, stems and
leaves – of Maclura pomifera.
1. INTRODUCTION
Maclura pomifera (Raf.) C.K.Schneid. (Moraceae), “Osage orange”, is a very common
tree native to the mid-western and south-eastern United States, however, species has been
introduced into many countries including Czech Republic. The types of secondary
metabolites isolated from different parts of Osage orange belong to the different classes,
such as flavonoids and isoflavonoids (especially prenylated), xanthones, stilbenes and
triterpenes. Many phytochemical studies are focused on the multiple fruits due to
presence of pharmacologically interesting isoflavonoids osajin and pomiferin [1].
Pomiferin is studied as a potent histone deacetylase inhibitor [2]. However,
pharmacologically active secondary metabolites have been detected also in other plant
parts. Xanthones (osajaxanthone, alvaxanthone, macluraxanthone, 8prenyltoxyloxanthone)
and flavanones (euchrestaflavanone B and euchrestaflavanone C)
have been found in bark of Osage orange [3]. Stilbenes (such as oxyresveratrol) have been
found in heartwood [4].
Type of compound Plant part Pharmacological properties Citation
Prenylated isoflavones –
pomiferin, osajin
Multiple
fruits
Histone deacetylase inhibitor
(pomiferin)
Antioxidant properties
Cytotoxic properties
Prenylated isoflavones – Multiple Anti-inflammatory and [8]
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[2]
[1]
[5]
[6]
[7]