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Stop Press - Last Minute Addition to July 2013 Edition
Immunoglobulin Test Kit
5 vials
The five immunoglobulin or antibodies involved in the immune system....
Immunoglobulin (Ig), also known as an antibody (Ab), is a large Y-shaped protein produced by B-cells that
is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The
antibody recognizes a unique part of the foreign target, called an antigen. Each tip of the “Y” of an antibody
contains a paratope (a structure analogous to a lock) that is specific for one particular epitope (similarly
analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this
binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune
system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for
its invasion and survival). The production of antibodies is the main function of the humoral immune system.
IG 01 IgA
Found in mucosal areas, such as the gut, respiratory tract and urogenital tract, and prevents colonization
by pathogens. Also found in saliva, tears, and breast milk.
IG 02 IgD
Functions mainly as an antigen receptor on B cells that have not been exposed to antigens. Has
been shown to activate basophils and mast cells to produce antimicrobial factors.
IG 03 IgE
Binds to allergens and triggers histamine release from mast cells and basophils, and is involved in
allergy. Also protects against parasitic worms.
IG 04 IgG
Provides the majority of antibody-based immunity against invading pathogens. The only antibody
capable of crossing the placenta to give passive immunity to the foetus.
IG 05 IgM
Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient
IgG.
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